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Literature summary for 3.4.24.11 extracted from
- Characterization of endopeptidase 3.4.24.11 ( enkephalinase ) activity in human plasma and cerebrospinal fluid (1990), Biochem. Pharmacol., 39, 1353-1356.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Leu5-enkephalin | - |
Homo sapiens |  |
| Leu5-enkephalin | - |
Mus musculus | |
| Leu5-enkephalin | hydrolysis of succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide | Rattus norvegicus | |
| Met5-enkephalin | - |
Homo sapiens | |
| Met5-enkephalin | - |
Mus musculus | |
| Met5-enkephalin | hydrolysis of succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide | Rattus norvegicus | |
| phosphoramidon | - |
Homo sapiens | |
| phosphoramidon | - |
Mus musculus | |
| phosphoramidon | - |
Rattus norvegicus | |
| thiorphan | - |
Homo sapiens | |
| thiorphan | - |
Mus musculus | |
| thiorphan | - |
Rattus norvegicus | |
| thiorphan-NH2 | - |
Homo sapiens | |
| thiorphan-NH2 | - |
Mus musculus | |
| thiorphan-NH2 | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.043 | - |
succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide | enzyme from amniotic fluid | Homo sapiens | |
| 0.052 | - |
succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide | - |
Rattus norvegicus | |
| 0.054 | - |
succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide | enzyme from cerebrospinal fluid | Homo sapiens | |
| 0.058 | - |
succinyl-Ala-Ala-Phe-AMC | plasma enzyme | Homo sapiens | |
| 0.073 | - |
succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
| membrane | bound | Rattus norvegicus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zinc | - |
Homo sapiens | |
| Zinc | zinc-containing metalloenzyme | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| amniotic fluid | - |
Homo sapiens | - |
| cerebrospinal fluid | - |
Homo sapiens | - |
| plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide + H2O | - |
Mus musculus | succinyl-Ala-Ala + Phe-4-methylcoumarin 7-amide | - |
? | |
| succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | succinyl-Ala-Ala + Phe-4-methylcoumarin 7-amide | - |
? | |
| succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide + H2O | - |
Rattus norvegicus | succinyl-Ala-Ala + Phe-4-methylcoumarin 7-amide | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Mus musculus |
| 7 | - |
- |
Homo sapiens |
| 7 | - |
- |
Rattus norvegicus |
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