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Literature summary for 3.4.24.11 extracted from

  • Landry, C.; Santagata, P.; Bawab, W.; Fournie-Zaluski, M.C.; Roques, B.P.; Vinay, P.; Crine, P.
    Characterization of neutral endopeptidase 24.11 in dog glomeruli (1993), Biochem. J., 291, 773-779.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.11

Inhibitors

Inhibitors Comment Organism Structure
2-[(3-iodohydroxy)phenylmethyl]-4-N-[3-hydroxyamino-3-oxo-1-phenylmethylpropyl]-amino-4-oxobutanoic acid i.e. RB104, highly selective and potent inhibitor Canis lupus familiaris
phosphoramidon
-
 Canis lupus familiaris
thiorphan
-
 Canis lupus familiaris

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.07
-
 D-Ala2-Leu5-enkephalin enzyme from tubules Canis lupus familiaris
0.076
-
 D-Ala2-Leu5-enkephalin enzyme from glomeruli Canis lupus familiaris

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane glomerular enzyme is membrane-bound Canis lupus familiaris 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
94000
-
 x * 94000, enzyme from tubules, SDS-PAGE Canis lupus familiaris
104000
-
 x * 104000, enzyme from glomeruli, SDS-PAGE Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Canis lupus familiaris the enzyme may play an important role as regulator of plasma-derived peptides in the nephron ?
-
 ?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification glycoprotein Canis lupus familiaris

Source Tissue

Source Tissue Comment Organism Textmining
kidney glomeruli, tubules Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Ala2-Leu5-enkephalin + H2O i.e. Tyr-D-Ala-Gly-Phe-Leu Canis lupus familiaris Tyr-D-Ala-Gly + Phe-Leu
-
 ?
additional information the enzyme may play an important role as regulator of plasma-derived peptides in the nephron Canis lupus familiaris ?
-
 ?

Subunits

Subunits Comment Organism
? x * 94000, enzyme from tubules, SDS-PAGE Canis lupus familiaris
? x * 104000, enzyme from glomeruli, SDS-PAGE Canis lupus familiaris

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
19
-
 D-Ala2-Leu5-enkephalin enzyme from tubules Canis lupus familiaris
20.7
-
 D-Ala2-Leu5-enkephalin enzyme from glomeruli Canis lupus familiaris