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Literature summary for 3.4.24.11 extracted from
- Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones (1989), FASEB J., 3, 145-151.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Oryctolagus cuniculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E584D | no activity | Rattus norvegicus |
| E584V | no activity | Rattus norvegicus |
| H583F | enzymatic activity and Zn-directed inhibitor binding is abolished | Rattus norvegicus |
| H587F | enzymatic activity and Zn-directed inhibitor binding is abolished | Rattus norvegicus |
| H637F | no effect on activity | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Acetorphan | - |
Homo sapiens |  |
| N-[(2RS)-3-hydroxyaminocarbonyl-2-benzyl-1-oxopropyl]-Gly | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
| membrane | - |
Rattus norvegicus | 16020 | - |
| membrane | axonal membranes, including those in synaptic junctions | Sus scrofa | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zinc | - |
Sus scrofa | |
| Zinc | cofactor | Homo sapiens | |
| Zinc | cofactor | Rattus norvegicus | |
| Zinc | cofactor | Oryctolagus cuniculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme is the major inactivator of enkephalin in brain | ? | - |
? | |
| additional information | Rattus norvegicus | the enzyme is the major inactivator of enkephalin in brain | ? | - |
? | |
| additional information | Oryctolagus cuniculus | the enzyme is the major inactivator of enkephalin in brain | ? | - |
? | |
| additional information | Homo sapiens | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | ? | - |
? | |
| additional information | Rattus norvegicus | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | ? | - |
? | |
| additional information | Sus scrofa | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | ? | - |
? | |
| additional information | Oryctolagus cuniculus | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | - |
Sus scrofa |
| side-chain modification | five potential N-linked glycosylation sites | Oryctolagus cuniculus |
| side-chain modification | six potential N-linked glycosylation sites | Homo sapiens |
| side-chain modification | six potential N-linked glycosylation sites | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | in globus pallidus and substantia nigra much of the enzyme is associated with presynaptic nerve terminals originating from efferent striatal neurons | Rattus norvegicus | - |
| brain | corpus striatum and globus pallidus | Sus scrofa | - |
| central nervous system | - |
Homo sapiens | - |
| central nervous system | - |
Rattus norvegicus | - |
| central nervous system | - |
Sus scrofa | - |
| central nervous system | - |
Oryctolagus cuniculus | - |
| epithelium | - |
Homo sapiens | - |
| epithelium | - |
Rattus norvegicus | - |
| epithelium | - |
Oryctolagus cuniculus | - |
| fibroblast | - |
Homo sapiens | - |
| fibroblast | - |
Rattus norvegicus | - |
| fibroblast | - |
Oryctolagus cuniculus | - |
| intestine | - |
Homo sapiens | - |
| intestine | - |
Rattus norvegicus | - |
| intestine | - |
Oryctolagus cuniculus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | renal brush border | Sus scrofa | - |
| kidney | renal brush border | Oryctolagus cuniculus | - |
| neutrophil | - |
Homo sapiens | - |
| neutrophil | - |
Rattus norvegicus | - |
| neutrophil | - |
Oryctolagus cuniculus | - |
| Schwann cell | present in many, but not all Schwann cell membranes | Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-neoendorphin + H2O | - |
Homo sapiens | ? | - |
? | |
| alpha-neoendorphin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| alpha-neoendorphin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| angiotensin I + H2O | - |
Homo sapiens | ? | - |
? | |
| angiotensin I + H2O | - |
Rattus norvegicus | ? | - |
? | |
| angiotensin I + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| angiotensin II + H2O | - |
Homo sapiens | ? | - |
? | |
| angiotensin II + H2O | - |
Rattus norvegicus | ? | - |
? | |
| angiotensin II + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O | - |
Homo sapiens | ? | - |
? | |
| Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O | - |
Sus scrofa | ? | - |
? | |
| Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O | - |
Homo sapiens | ? | - |
? | |
| Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O | - |
Sus scrofa | ? | - |
? | |
| Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| Atrial natriuretic factor + H2O | - |
Homo sapiens | ? | - |
? | |
| Atrial natriuretic factor + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Atrial natriuretic factor + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| beta-lipotropin(61-69) + H2O + H2O | - |
Homo sapiens | ? | - |
? | |
| beta-lipotropin(61-69) + H2O + H2O | - |
Rattus norvegicus | ? | - |
? | |
| beta-lipotropin(61-69) + H2O + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| beta-neoendorphin + H2O | - |
Homo sapiens | ? | - |
? | |
| beta-neoendorphin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| beta-neoendorphin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
| bradykinin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| bradykinin + H2O | - |
Sus scrofa | ? | - |
? | |
| bradykinin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| dynorphin + H2O | - |
Homo sapiens | ? | - |
? | |
| dynorphin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| dynorphin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| enkephalin + H2O | hydrolysis at Gly3-Phe4 | Homo sapiens | ? | - |
? | |
| enkephalin + H2O | hydrolysis at Gly3-Phe4 | Rattus norvegicus | ? | - |
? | |
| enkephalin + H2O | hydrolysis at Gly3-Phe4 | Oryctolagus cuniculus | ? | - |
? | |
| FMRF amide + H2O | - |
Homo sapiens | ? | - |
? | |
| FMRF amide + H2O | - |
Rattus norvegicus | ? | - |
? | |
| FMRF amide + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| gamma-endorphin + H2O | - |
Homo sapiens | ? | - |
? | |
| gamma-endorphin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| gamma-endorphin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| gastrin + H2O | - |
Homo sapiens | ? | - |
? | |
| gastrin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| gastrin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| gastrin G-17 + H2O | - |
Homo sapiens | ? | - |
? | |
| gastrin releasing peptide-10 + H2O | - |
Homo sapiens | ? | - |
? | |
| gastrin releasing peptide-10 + H2O | - |
Rattus norvegicus | ? | - |
? | |
| gastrin releasing peptide-10 + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O | - |
Homo sapiens | His-Lys-Thr-Asp-Ser + Phe-Val-Gly + Leu-Met-NH2 | - |
? | |
| His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O | - |
Rattus norvegicus | His-Lys-Thr-Asp-Ser + Phe-Val-Gly + Leu-Met-NH2 | - |
? | |
| His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O | - |
Sus scrofa | His-Lys-Thr-Asp-Ser + Phe-Val-Gly + Leu-Met-NH2 | - |
? | |
| His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O | - |
Oryctolagus cuniculus | His-Lys-Thr-Asp-Ser + Phe-Val-Gly + Leu-Met-NH2 | - |
? | |
| insulin B chain + H2O | - |
Homo sapiens | ? | - |
? | |
| insulin B chain + H2O | - |
Rattus norvegicus | ? | - |
? | |
| insulin B chain + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| interleukin 1beta + H2O | - |
Homo sapiens | ? | - |
? | |
| interleukin 1beta + H2O | - |
Rattus norvegicus | ? | - |
? | |
| interleukin 1beta + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| Luteinizing hormone-releasing hormone + H2O | - |
Homo sapiens | ? | - |
? | |
| Luteinizing hormone-releasing hormone + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Luteinizing hormone-releasing hormone + H2O | - |
Sus scrofa | ? | - |
? | |
| Luteinizing hormone-releasing hormone + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| Met-enkephalin-Arg6-Gly7-Leu + H2O | - |
Homo sapiens | ? | - |
? | |
| Met-enkephalin-Arg6-Gly7-Leu + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Met-enkephalin-Arg6-Gly7-Leu + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| Met-Leu-Phe + H2O | chemotactic peptide | Homo sapiens | ? | - |
? | |
| Met-Leu-Phe + H2O | chemotactic peptide | Rattus norvegicus | ? | - |
? | |
| Met-Leu-Phe + H2O | chemotactic peptide | Oryctolagus cuniculus | ? | - |
? | |
| Met5-enkephalin-Arg6-Phe7 + H2O | - |
Homo sapiens | ? | - |
? | |
| Met5-enkephalin-Arg6-Phe7 + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Met5-enkephalin-Arg6-Phe7 + H2O | - |
Sus scrofa | ? | - |
? | |
| Met5-enkephalin-Arg6-Phe7 + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| additional information | the enzyme is the major inactivator of enkephalin in brain | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is the major inactivator of enkephalin in brain | Rattus norvegicus | ? | - |
? | |
| additional information | the enzyme is the major inactivator of enkephalin in brain | Oryctolagus cuniculus | ? | - |
? | |
| additional information | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | Homo sapiens | ? | - |
? | |
| additional information | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | Rattus norvegicus | ? | - |
? | |
| additional information | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | Sus scrofa | ? | - |
? | |
| additional information | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | Oryctolagus cuniculus | ? | - |
? | |
| neurokinin B + H2O | - |
Homo sapiens | ? | - |
? | |
| neurokinin B + H2O | - |
Rattus norvegicus | ? | - |
? | |
| neurokinin B + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| neurotensin + H2O | - |
Homo sapiens | ? | - |
? | |
| neurotensin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| neurotensin + H2O | - |
Sus scrofa | ? | - |
? | |
| neurotensin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| oxytocin + H2O | - |
Homo sapiens | ? | - |
? | |
| oxytocin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| oxytocin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| physalaemin + H2O | - |
Homo sapiens | ? | - |
? | |
| physalaemin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| physalaemin + H2O | - |
Sus scrofa | ? | - |
? | |
| physalaemin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
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