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Literature summary for 3.4.24.11 extracted from

  • de Oliveira, R.W.; Julian, G.S.; Perry, J.C.; Tufik, S.; Chagas, J.R.
    Chronic intermittent hypoxia induces changes on the expression and activity of neprilysin (EC 3.4.24.11) in the brain of rats (2018), Neurosci. Lett., 678, 43-47 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
quantitative real-time PCR enzyme expression analysis Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
thiorphan a NEP-specific inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P07861
-
-
Rattus norvegicus Wistar-Hannover P07861
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain six-week intermittent hypoxia increases NEP expression and activity, selectively in temporal cortex, but not in the hippocampus and frontal cortex. The increase in NEP activity and expression is reverted followed by two weeks recovery in normoxia Rattus norvegicus
-
additional information expression and activity of NEP in cognitive-related brain structures of rats submitted to chronic intermittent hypoxia (CIH) Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
-
Rattus norvegicus succinyl-Ala-Ala-Phe + 7-amino-4-methylcoumarin
-
?
succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
-
Rattus norvegicus Wistar-Hannover succinyl-Ala-Ala-Phe + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
NEP
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus six-week intermittent hypoxia increases NEP expression and activity, selectively in temporal cortex, but not in the hippocampus and frontal cortex. The increase in NEP activity and expression is reverted followed by two weeks recovery in normoxia up

General Information

General Information Comment Organism
physiological function neprilysin (NEP) is responsible for degrading several substrates related to cognition Rattus norvegicus