Cloned (Comment) | Organism |
---|---|
recombinant viral expression of NEP in primary neurons | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | viral expression of NEP in primary neurons leads to effective clearance of amylod-beta in vitro | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08473 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
neuron | CA1 neuron, NEP is almost exclusively expressed in neurons. Presynaptic terminals and intracellular locations are likely the main sites of NEP-mediated amyloid-beta degradation | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid-beta1-40 + H2O | a synthetic peptide | Homo sapiens | ? | - |
? | |
amyloid-beta1-42 + H2O | a synthetic peptide | Homo sapiens | ? | - |
? | |
amyloid-beta4-40 + H2O | a synthetic peptide | Homo sapiens | ? | - |
? | |
amyloid-beta4-42 + H2O | a synthetic peptide | Homo sapiens | ? | - |
? | |
additional information | analysis of intact amyloid-beta peptides and their NEP cleavage products by mass spectrometry. 73% of amyloid-beta4-40, 31% of amyloid-beta4-42, 45% of amyloid-beta1-40, and 18% of amyloid-beta1-42 degradation resulting from NEP catalyzed hydrolysis. Amyloid-beta4-9/amyloid-beta1-9, amyloid-beta10-17, and amyloid-beta20-30 are the major enzymatic products | Homo sapiens | ? | - |
- |
|
additional information | analysis of intact amyloid-beta peptides and their NEP cleavage products by mass spectrometry. 73% of amyloid-beta4-40, 31% of amyloid-beta4-42, 45% of amyloid-beta1-40, and 18% of amyloid-beta1-42 degradation resulting from NEP catalyzed hydrolysis. Amyloid-beta4-9/amyloid-beta1-9, amyloid-beta10-17, and amyloid-beta20-30 are the major enzymatic products | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NEP | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | a lack of 465 NEP accelerates hippocampal neuron loss in relatively young transgenic mice expressing amyloid-beta4-42 | Homo sapiens |
physiological function | N-terminal truncated Abeta4-42 is a substrate for neprilysin degradation in vitro and in vivo | Homo sapiens |