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Literature summary for 3.4.24.11 extracted from

  • Chin-Chan, M.; Segovia, J.; Quintanar, L.; Arcos-Lopez, T.; Hersh, L.B.; Chow, K.M.; Rodgers, D.W.; Quintanilla-Vega, B.
    Mercury reduces the enzymatic activity of neprilysin in differentiated SH-SY5Y cells (2015), Toxicol. Sci., 145, 128-137.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.11

Inhibitors

Inhibitors Comment Organism Structure
Hg2+ 0.001-0.05 mM, modifies the recombinant enzyme conformation, and highly reduces the enzyme activity. Hg2+ incubation increases NEP protein levels, but does not change NEP mRNA levels nor the levels of the amyloid intracellular domain peptide, a protein fragment with transcriptional activity. The Hg2+-induced inhibition of the enzyme activity may be mediated by a conformational change resulting in reduced amyloid beta1-42 degradation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information Pb2+ slightly modifies the recombinant enzyme conformation, but does not affect the enzyme activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid beta peptide + H2O Homo sapiens
-
 ?
-
 ?
amyloid beta peptide1-42 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08473
-
-

Source Tissue

Source Tissue Comment Organism Textmining
central nervous system
-
 Homo sapiens
-
neuron
-
 Homo sapiens
-
SH-SY5Y cell differentiated Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta peptide + H2O
-
 Homo sapiens ?
-
 ?
amyloid beta peptide1-42 + H2O
-
 Homo sapiens ?
-
 ?
glutaryl-Ala-Ala-Phe-4-methoxy-2-naphthylamide + H2O
-
 Homo sapiens glutaryl-Ala-Ala + Phe-4-methoxy-2-naphthylamide
-
 ?

Synonyms

Synonyms Comment Organism
NEP
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 assay at Homo sapiens