Application | Comment | Organism |
---|---|---|
medicine | since accumulation of neurotoxic amyloid beta peptide aggregates in the brain appears to be a causative agent in the pathophysiology of Alzheimer's disease, increased clearance of amyloid beta peptide resulting from overexpression of the enzyme exhibits therapeutic potential for Alzheimer's disease | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | a zinc metalloprotease | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta peptide + H2O | Homo sapiens | degradation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08473 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta peptide + H2O | degradation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NEP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | protein-ligand docking calculations predict S2' subsite residues Arg102 and Arg110 of the enzyme to participate in specific interactions with amyloid beta peptide and are a target for modification of the enzyme for higher specificity against amyloid beta peptide | Homo sapiens |