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Literature summary for 3.4.24.11 extracted from

  • Kuruppu, S.; Rajapakse, N.W.; Minond, D.; Smith, A.I.
    Production of soluble neprilysin by endothelial cells (2014), Biochem. Biophys. Res. Commun., 446, 423-427.
    View publication on PubMed
Search for more literature for 3.4.24.11

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by 4-(2-butylbenzyl)-5-(4-hydroxybenzyl)-1-[1-(2-[[6-(4-hydroxybenzyl)-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl)-3-(naphthalen-2-yl)propan-2-yl]piperazine-2,3-dione and 4-(cyclopentylmethyl)-5-(4-hydroxybenzyl)-1-[1-(2-[[6-(4-hydroxybenzyl)-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl)-3-(naphthalen-2-yl)propan-2-yl]piperazine-2,3-dione Homo sapiens
thiorphan
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-
additional information the enzyme is released from endothelial cells via exosomes, the process is dependent on ADAM-17 protease Homo sapiens
-
-
soluble
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bradykinin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08473
-
-

Source Tissue

Source Tissue Comment Organism Textmining
EA.hy926 cell
-
 Homo sapiens
-
endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(2,4-dinitrophenyl) + H2O bradykinin-based quenched fluorescent substrate assay Homo sapiens (7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala + Phe-Lys-(2,4-dinitrophenyl)
-
 ?
bradykinin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CALLA
-
 Homo sapiens
CD10
-
 Homo sapiens
common acute lymphoblastic leukemia antigen
-
 Homo sapiens
endopeptidase-24.11
-
 Homo sapiens
enkephalinase
-
 Homo sapiens
NEP
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction treatment of cells with TPI2155-14 and TPI2155-17, specific inhibitors for ADAM-17 protease, EC 3.4.24.86, results in a significant decrease in neprilysin activity in media, implicating a possible role for ADAM-17 in neprilysin release Homo sapiens
metabolism the non-membrane bound form of neprilysin with catalytic activity has the potential to cleave substrates throughout the blood circulation with systemic effects. A likely role of exosomes and protease ADAM-17 in release of the enzyme, overview Homo sapiens