Activating Compound | Comment | Organism | Structure |
---|---|---|---|
estrogen | estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phosphoramidon | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuroblastoma cell line | in neuroblastoma SH-SY5Y cells neprilysin expression is up-regulated estrogen | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-amyloid peptide + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neprilysin | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | in neuroblastoma SH-SY5Y cells neprilysin expression is up-regulated estrogen. Upregulation of neprilysin by estrogen is dependent on both estrogen receptor alpha and beta, and ligand-activated estrogen receptor regulates expression of neprilysin through physical interactions between estrogen receptor and estrogen response elements identified in the neprilysin gene | up |