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Literature summary for 3.4.24.11 extracted from

  • Belyaev, N.; Nalivaeva, N.; Makova, N.; Turner, A.
    Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: Implications for Alzheimer disease (2009), EMBO Rep., 10, 94-100.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
neuroblastoma cell line two neuroblastoma cell lines differing substantially in NEP expression are compared: using chromatin immunoprecipitation it is shown that amyloid precursor protein is bound directly to the NEP promoter in high NEP-expresser (NB7) cells but not in low-expresser (SH-SY5Y) cells. The methylation status of the NEP promoter does not regulate expression in these cells, whereas the histone deacetylase inhibitors trichostatin A and valproate partly restore NEP expression and activity in SH-SY5Y cells Homo sapiens
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neuron chromatin immunoprecipitation analysis demonstrates amyloid precursor protein binding to tht NEP promoter in primary neurons Rattus norvegicus
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Synonyms

Synonyms Comment Organism
NEP
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 Homo sapiens
NEP
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 Rattus norvegicus
neprilysin
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 Homo sapiens
neprilysin
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 Rattus norvegicus

Expression

Organism Comment Expression
Homo sapiens treatment of neuroblastoma cells NB7 with 10 mM L685,458 a potent gamma-secretase inhibitor substantially reduces NEP expression down
Homo sapiens treatment of cells with and histone deacetylase inhibitor sodium valproate or trichostatin A significantly increases NEP mRNA levels and NEP enzymatic activity in neuroblastoma SH-SY5Y cells up