Literature summary for 3.4.24.11 extracted from

Rose, J.B.; Crews, L.; Rockenstein, E.; Adame, A.; Mante, M.; Hersh, L.B.; Gage, F.H.; Spencer, B.; Potkar, R.; Marr, R.A.; Masliah, E.
Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease (2009), J. Neurosci., 29, 1115-1125.

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Application

Application	Comment	Organism
medicine	overexpression neprilysin at low levels in transgenic mouse affects primarily the levels of neuropeptide Y compared with other neuropeptides. Neprilysin cleaves neuropeptide Y in C-terminal fragments, whereas silcencing neprilysin reduces neuropeptide Y processing. Infusion of the most abundant neuropeptide Y fragments 21-36 and 31-36 into the brain of amyloid precursor protein transgenic mice ameliorates the neurodegenerative pathology in this model. The amidated neuropeptide Y fragments protect human neuronal cultures from the neurotoxic effects of amyloid beta	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression in transgenic mice	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	overexpression neprilysin at low levels in transgenic mouse affects primarily the levels of neuropeptide Y compared with other neuropeptides. Neprilysin cleaves neuropeptide Y in C-terminal fragments, whereas silcencing neprilysin reduces neuropeptide Y processing. Infusion of the most abundant neuropeptide Y fragments 21-36 and 31-36 into the brain of amyloid precursor protein transgenic mice ameliorates the neurodegenerative pathology in this model. The amidated neuropeptide Y fragments protect human neuronal cultures from the neurotoxic effects of amyloid beta	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
neuropeptide Y + H2O	Homo sapiens	-	truncated neuropeptide Y + C-terminal fragments of neuropeptide Y	neuropeptide Y 21-36 and 31-36 are the most abundant fragments generated in vivo	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	expression in mouse	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
neuropeptide Y + H2O	-	Homo sapiens	truncated neuropeptide Y + C-terminal fragments of neuropeptide Y	neuropeptide Y 21-36 and 31-36 are the most abundant fragments generated in vivo	?

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Release 2023.1 (January 2023)