Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | application of aldosterone, atrial natriuretic peptide, asymmetric dimethylarginine, and angiotensin peptides fail to cause down-regulation of renal neprilysin expression in vitro | Sus scrofa |
Organism | UniProt | Comment | Textmining |
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Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | renal mRNA expression and protein of neprilysin is substantially downregulated during rapid atrial pacing. Irbesartan therapy does not prevent down-regulation of neprilysin. In contrast, TGF-beta1 mRNA expression is up-regulated. Collagen and angiotensin II type 1 receptor expression are not significantly altered by rapid atrial pacing. Application of aldosterone, atrial natriuretic peptide, asymmetric dimethylarginine, and angiotensin peptides fail to cause down-regulation of renal neprilysin expression in vitro | Sus scrofa | - |