Literature summary for 3.4.24.11 extracted from

Dolcini, V.; Dunys, J.; Sevalle, J.; Chen, F.; Guillot-Sestier, M.V.; St George-Hyslop, P.; Fraser, P.E.; Checler, F.
TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin (2008), Biochem. Biophys. Res. Commun., 371, 69-74.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	both staurosporine-stimulated caspase-3 activation, p53 and neprilysin expression and activity are not affected by over-expression or depletion of presenilin complex component TMP21	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	both staurosporine-stimulated caspase-3 activation, p53 and neprilysin expression and activity are not affected by over-expression or depletion of presenilin complex component TMP21	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	both staurosporine-stimulated caspase-3 activation, p53 and neprilysin expression and activity are not affected by over-expression or depletion of presenilin complex component TMP21	Homo sapiens	-

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Release 2023.1 (January 2023)