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Literature summary for 3.4.24.11 extracted from
- Neprilysin activity and expression are controlled by nicastrin (2006), J. Neurochem., 97, 1052-1056.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | nicastrin controls neprilysin at a transcriptional level by contributing to the production of the beta-amyloid precursor protein intracellular domain with the gamma-secretase complex | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | embryonic | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | nicastrin controls neprilysin at a transcriptional level by contributing to the production of the beta-amyloid precursor protein intracellular domain with the gamma-secretase complex | Mus musculus | ? | - |
? | |
| succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide + H2O | - |
Mus musculus | succinyl-Ala-Ala + Phe-4-methylcoumarin 7-amide | - |
? | |
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Release 2023.1 (January 2023)
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