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Literature summary for 3.4.24.1 extracted from

  • McBride, D.W.; Gren, E.C.K.; Kelln, W.; Hayes, W.K.; Zhang, J.H.
    Crotalus atrox disintegrin reduces hemorrhagic transformation by attenuating matrix metalloproteinase-9 activity after middle cerebral artery occlusion in hyperglycemic male rats (2018), J. Neurosci. Res., 2018, 1-11 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.1

Application

Application Comment Organism
medicine disintegrins found in Crotalus atrox venom may have therapeutic potential for reducing hemorrhagic transformation after ischemic stroke Crotalus atrox

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by batimastat and prinomastat Crotalus atrox

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Crotalus atrox
-
-

Organism

Organism UniProt Comment Textmining
Crotalus atrox P68520
-
-

Source Tissue

Source Tissue Comment Organism Textmining
venom several isoforms of disintegrin Crotatroxi Crotalus atrox
-

Synonyms

Synonyms Comment Organism
Crotatroxin
-
 Crotalus atrox
disintegrin
-
 Crotalus atrox
snake venom disintegrin
-
 Crotalus atrox

General Information

General Information Comment Organism
physiological function disintegrin Crotatroxin from venom of Crotalus atrox has targets within the coagulation cascade, including receptors on platelets. The disintegrin from venom can attenuates hemorrhagic transformation by preventing activation of matrix metalloproteinase-9 after middle cerebral artery occlusion (MCAO) in hyperglycemic male Sprague-Dawley rats Crotalus atrox