Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.1 extracted from

  • Suntravat, M.; Jia, Y.; Lucena, S.E.; Sanchez, E.E.; Perez, J.C.
    cDNA cloning of a snake venom metalloproteinase from the eastern diamondback rattlesnake (Crotalus adamanteus), and the expression of its disintegrin domain with anti-platelet effects (2013), Toxicon, 64, 43-54.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.1

Application

Application Comment Organism
medicine recombinant protease inhibits platelet adhesion to fibrinogen with an estimated IC50 of 1 nM. It inhibits collagen- (IC50 is 18 nM) and ADP-induced (IC50 is 6 nM) platelet aggregation, and also inhibits platelet function on clot retraction Crotalus adamanteus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
8000
-
 x * 8000, calculated Crotalus adamanteus

Organism

Organism UniProt Comment Textmining
Crotalus adamanteus J9Z332
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification deduced amino acid sequence contains a signal peptide Crotalus adamanteus

Source Tissue

Source Tissue Comment Organism Textmining

Subunits

Subunits Comment Organism
? x * 8000, calculated Crotalus adamanteus
More deduced amino acid sequence consists of a signal peptide, a pro-domain, a metalloproteinase domain, a spacer, and a disintegrin domain Crotalus adamanteus

Synonyms

Synonyms Comment Organism
Cam-dis
-
 Crotalus adamanteus
zinc metalloproteinase-disintegrin VMP-II
-
 Crotalus adamanteus

pI Value

Organism Comment pI Value Maximum pI Value
Crotalus adamanteus calculated
-
 4.5

General Information

General Information Comment Organism
physiological function recombinant protease inhibits platelet adhesion to fibrinogen with an estimated IC50 of 1 nM. It inhibits collagen- (IC50 is 18 nM) and ADP-induced (IC50 is 6 nM) platelet aggregation, and also inhibits platelet function on clot retraction Crotalus adamanteus