BRENDA - Enzyme Database
show all sequences of 3.4.23.B9

Bovine leukemia virus protease: comparison with human T-lymphotropic virus and human immunodeficiency virus proteases

Sperka, T.; Miklossy, G.; Tie, Y.; Bagossi, P.; Zahuczky, G.; Boross, P.; Matuz, K.; Harrison, R.W.; Weber, I.T.; Toezser, J.; J. Gen. Virol. 88, 2052-2063 (2007)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
DTT
assay with
bovine leukemia virus
EDTA
assay with
bovine leukemia virus
Engineering
Protein Variants
Commentary
Organism
N38D
Km: 0.18 mM (KTKVLVVQPK), kcat: 0.023/sec (KTKVLVVQPK)
bovine leukemia virus
V57I
Km: 0.0075 mM (KTKVLVVQPK), kcat: 0.006/sec (KTKVLVVQPK)
bovine leukemia virus
V57I/L58G/A60I
Km: 0.03 mM (KTKVLVVQPK), kcat: 0.016/sec (KTKVLVVQPK)
bovine leukemia virus
W99V
Km: 0.006 mM (KTKVLVVQPK), kcat: 0.003/sec (KTKVLVVQPK)
bovine leukemia virus
Inhibitors
Inhibitors
Commentary
Organism
Structure
Ala-Pro-Gln-Val-Leu-r-Pro-Val-Met-His-Pro
-
bovine leukemia virus
Ala-Pro-Gln-Val-Sta-Val-Met-His-Pro
-
bovine leukemia virus
amprenavir
-
bovine leukemia virus
DMP-323
-
bovine leukemia virus
HBY-793
a compound which inhibits EIAV PR
bovine leukemia virus
indinavir
-
bovine leukemia virus
KH 164
modest inhibitor of MMLV PR
bovine leukemia virus
LP-149
inhibitor of FIV PR
bovine leukemia virus
Lys-Thr-Lys-Val-Leu-r-Val-Val-Gln-Pro-Lys
-
bovine leukemia virus
Lys-Thr-Lys-Val-Sta-Val-Gln-Pro-Gly
-
bovine leukemia virus
nelfinavir
-
bovine leukemia virus
ritonavir
-
bovine leukemia virus
saquinavir
-
bovine leukemia virus
UK 88.947
a compound which inhibits HIV-1PR
bovine leukemia virus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.006
-
KTKVLVVQPK
value below 0.006, mutant W99V
bovine leukemia virus
0.0075
-
KTKVLVVQPK
mutant V57I
bovine leukemia virus
0.01
-
KPKVLVVQPK
value below 0.01, P4-substituted peptide
bovine leukemia virus
0.01
-
KTAVLVVQPK
value below 0.01, P3-substituted peptide
bovine leukemia virus
0.01
-
KTKILVVQPK
value below 0.01, P2-substituted peptide
bovine leukemia virus
0.01
-
KTKVAVVQPK
P1-substituted peptide
bovine leukemia virus
0.01
-
KTKVGVVQPK
value below 0.01, P1-substituted peptide
bovine leukemia virus
0.01
-
KTKVLFVQPK
value below 0.01, P1'-substituted peptide
bovine leukemia virus
0.01
-
KTLVLVVQPK
value below 0.01, P3-substituted peptide
bovine leukemia virus
0.01
-
KTSVLVVQPK
value below 0.01, P3-substituted peptide
bovine leukemia virus
0.01
-
KTVVLVVQPK
value below 0.01, P3-substituted peptide
bovine leukemia virus
0.01
-
KVKVLVVQPK
value below 0.01, P4-substituted peptide
bovine leukemia virus
0.01
-
TKVLVVQPK
-
bovine leukemia virus
0.011
-
KTKVLVVQPK
-
bovine leukemia virus
0.014
-
KTKVYVVQPK
P1-substituted peptide
bovine leukemia virus
0.015
-
KVLVVQPK
-
bovine leukemia virus
0.016
-
KTKVLSVQPK
P1'-substituted peptide
bovine leukemia virus
0.017
-
KTKVSVVQPK
P1-substituted peptide
bovine leukemia virus
0.02
-
KTGVLVVQPK
value below 0.02, P3-substituted peptide
bovine leukemia virus
0.02
-
KTKALVVQPK
value below 0.02, P2-substituted peptide
bovine leukemia virus
0.02
-
KTKFLVVQPK
value below 0.02, P2-substituted peptide
bovine leukemia virus
0.02
-
KTKVMVVQPK
value below 0.02, P1-substituted peptide
bovine leukemia virus
0.021
-
KGKVLVVQPK
P4-substituted peptide
bovine leukemia virus
0.021
-
KTKVLGVQPK
P1'-substituted peptide
bovine leukemia virus
0.021
-
KTKVLIVQPK
P1'-substituted peptide
bovine leukemia virus
0.021
-
KTKVLLVQPK
P1'-substituted peptide
bovine leukemia virus
0.022
-
KSKVLVVQPK
P4-substitutedpeptide
bovine leukemia virus
0.025
-
KTKLLVVQPK
P2-substituted peptide
bovine leukemia virus
0.026
-
KTDVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.026
-
KTKSLVVQPK
P2-substituted peptide
bovine leukemia virus
0.03
-
KLKVLVVQPK
value below 0.03, P4-substituted peptide
bovine leukemia virus
0.03
-
KTKVLVVQPK
mutant D97T/K98P/W99V
bovine leukemia virus
0.032
-
KTKVDVVQPK
P1-substituted peptide
bovine leukemia virus
0.033
-
KTKNLVVQPK
P2-substituted peptide
bovine leukemia virus
0.042
-
KAKVLVVQPK
P4-substitutedpeptide
bovine leukemia virus
0.042
-
KTFVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.043
-
KTKDLVVQPK
P2-substituted peptide
bovine leukemia virus
0.048
-
KDKVLVVQPK
P4-substitutedpeptide
bovine leukemia virus
0.048
-
KTKVFVVQPK
P1-substituted peptide
bovine leukemia virus
0.063
-
KTKVLPVQPK
P1'-substituted peptide
bovine leukemia virus
0.13
-
KTKVLKVQPK
P1'-substituted peptide
bovine leukemia virus
0.18
-
KTKVLVVQPK
mutant N38D
bovine leukemia virus
0.2
-
KTKGLVVQPK
P2-substituted peptide
bovine leukemia virus
Organism
Organism
UniProt
Commentary
Textmining
bovine leukemia virus
P10270
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
KAKVLVVQPK + H2O
P4-substituted peptide
681171
bovine leukemia virus
KAKVL + VVQPK
-
-
-
?
KDKVLVVQPK + H2O
P4-substituted peptide
681171
bovine leukemia virus
KDKVL + VVQPK
-
-
-
?
KGKVLVVQPK + H2O
P4-substituted peptide
681171
bovine leukemia virus
KGKVL + VVQPK
-
-
-
?
KLKVLVVQPK + H2O
P4-substituted peptide
681171
bovine leukemia virus
KLKVL + VVQPK
-
-
-
?
KPKVLVVQPK + H2O
P4-substituted peptide
681171
bovine leukemia virus
KPKVL + VVQPK
-
-
-
?
KSKVLVVQPK + H2O
P4-substituted peptide
681171
bovine leukemia virus
KSKVL + VVQPK
-
-
-
?
KTAVLVVQPK + H2O
P3-substituted peptide
681171
bovine leukemia virus
KTGVL + VVQPK
-
-
-
?
KTDVLVVQPK + H2O
P3-substituted peptide
681171
bovine leukemia virus
KTDVL + VVQPK
-
-
-
?
KTFVLVVQPK + H2O
P3-substituted peptide
681171
bovine leukemia virus
KTFVL + VVQPK
-
-
-
?
KTGVLVVQPK + H2O
P3-substituted peptide
681171
bovine leukemia virus
KTGVL + VVQPK
-
-
-
?
KTKALVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKAL + VVQPK
-
-
-
?
KTKDLVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKDL + VVQPK
-
-
-
?
KTKFLVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKFL + VVQPK
-
-
-
?
KTKGLVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKGL + VVQPK
-
-
-
?
KTKILVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKIL + VVQPK
-
-
-
?
KTKLLVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKLL + VVQPK
-
-
-
?
KTKNLVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKNL + VVQPK
-
-
-
?
KTKSLVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKSL + VVQPK
-
-
-
?
KTKVAVVQPK + H2O
P1-substituted peptide
681171
bovine leukemia virus
KTKVA + VVQPK
-
-
-
?
KTKVDVVQPK + H2O
P1-substituted peptide
681171
bovine leukemia virus
KTKVD + VVQPK
-
-
-
?
KTKVFVVQPK + H2O
P1-substituted peptide
681171
bovine leukemia virus
KTKVF + VVQPK
-
-
-
?
KTKVGVVQPK + H2O
P1-substituted peptide
681171
bovine leukemia virus
KTKVG + VVQPK
-
-
-
?
KTKVLDVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + DVQPK
-
-
-
?
KTKVLFVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + FVQPK
-
-
-
?
KTKVLGVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + GVQPK
-
-
-
?
KTKVLIVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + IVQPK
-
-
-
?
KTKVLKVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + KVQPK
-
-
-
?
KTKVLLVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + LVQPK
-
-
-
?
KTKVLPVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + PVQPK
-
-
-
?
KTKVLSVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + SVQPK
-
-
-
?
KTKVLVVQPK + H2O
-
681171
bovine leukemia virus
KTKVL + VVQPK
-
-
-
?
KTKVMVVQPK + H2O
P1-substituted peptide
681171
bovine leukemia virus
KTKVM + VVQPK
-
-
-
?
KTKVSVVQPK + H2O
P1-substituted peptide
681171
bovine leukemia virus
KTKVS + VVQPK
-
-
-
?
KTKVYVVQPK + H2O
P1-substituted peptide
681171
bovine leukemia virus
KTKVY + VVQPK
-
-
-
?
KTLVLVVQPK + H2O
P3-substituted peptide
681171
bovine leukemia virus
KTLVL + VVQPK
-
-
-
?
KTSVLVVQPK + H2O
P3-substituted peptide
681171
bovine leukemia virus
KTSVL + VVQPK
-
-
-
?
KTVVLVVQPK + H2O
P3-substituted peptide
681171
bovine leukemia virus
KTVVL + VVQPK
-
-
-
?
KVKVLVVQPK + H2O
P4-substituted peptide
681171
bovine leukemia virus
KVKVL + VVQPK
-
-
-
?
KVLVVQPK + H2O
-
681171
bovine leukemia virus
KVL + VVQPK
-
-
-
?
TKVLVVQPK + H2O
-
681171
bovine leukemia virus
TKVL + VVQPK
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
bovine leukemia virus protease
-
bovine leukemia virus
BVL PR
-
bovine leukemia virus
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
bovine leukemia virus
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.003
-
KTKVLVVQPK
mutant W99V
bovine leukemia virus
0.006
-
KTKVLVVQPK
mutant V57I
bovine leukemia virus
0.01
-
KTKVLDVQPK
value below 0.01, P1'-substituted peptide
bovine leukemia virus
0.016
-
KTKVLVVQPK
mutant D97T/K98P/W99V
bovine leukemia virus
0.07
-
KTKDLVVQPK
P2-substituted peptide
bovine leukemia virus
0.09
-
KTKVGVVQPK
P1-substituted peptide
bovine leukemia virus
0.11
-
KTKVDVVQPK
P1-substituted peptide
bovine leukemia virus
0.11
-
KTKVSVVQPK
P1-substituted peptide
bovine leukemia virus
0.11
-
KTLVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.12
-
KTKVLGVQPK
P1'-substituted peptide
bovine leukemia virus
0.13
-
KTKNLVVQPK
P2-substituted peptide
bovine leukemia virus
0.13
-
KTVVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.16
-
KPKVLVVQPK
P4-substituted peptide
bovine leukemia virus
0.17
-
KTDVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.18
-
KTAVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.18
-
KTKVLSVQPK
P1'-substituted peptide
bovine leukemia virus
0.19
-
KSKVLVVQPK
P4-substituted peptide
bovine leukemia virus
0.19
-
KTKGLVVQPK
P2-substituted peptide
bovine leukemia virus
0.2
-
KTSVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.2
-
KVKVLVVQPK
P4-substituted peptide
bovine leukemia virus
0.22
-
KAKVLVVQPK
P4-substituted peptide
bovine leukemia virus
0.23
-
KTKVLIVQPK
P1'-substituted peptide
bovine leukemia virus
0.23
-
KTKVLVVQPK
mutant N38D
bovine leukemia virus
0.24
-
KTKVMVVQPK
P1-substituted peptide
bovine leukemia virus
0.27
-
KTKVLVVQPK
-
bovine leukemia virus
0.28
-
KTKVLFVQPK
P1'-substituted peptide
bovine leukemia virus
0.29
-
KTKILVVQPK
P2-substituted peptide
bovine leukemia virus
0.29
-
KTKLLVVQPK
P2-substituted peptide
bovine leukemia virus
0.32
-
KTKFLVVQPK
P2-substituted peptide
bovine leukemia virus
0.34
-
KTKVAVVQPK
P1-substituted peptide
bovine leukemia virus
0.34
-
KTKVLLVQPK
P1'-substituted peptide
bovine leukemia virus
0.35
-
KTKALVVQPK
P2-substituted peptide
bovine leukemia virus
0.35
-
KTKSLVVQPK
P2-substituted peptide
bovine leukemia virus
0.35
-
TKVLVVQPK
-
bovine leukemia virus
0.36
-
KTKVLKVQPK
P1'-substituted peptide
bovine leukemia virus
0.44
-
KTFVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.58
-
KGKVLVVQPK
P4-substituted peptide
bovine leukemia virus
0.71
-
KVLVVQPK
-
bovine leukemia virus
0.74
-
KLKVLVVQPK
P4-substituted peptide
bovine leukemia virus
0.74
-
KTGVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.74
-
KTKVYVVQPK
P1-substituted peptide
bovine leukemia virus
0.85
-
KTKVLPVQPK
P1'-substituted peptide
bovine leukemia virus
0.9
-
KDKVLVVQPK
P4-substituted peptide
bovine leukemia virus
2
-
KTKVFVVQPK
P1-substituted peptide
bovine leukemia virus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.6
-
assay at
bovine leukemia virus
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.013
-
Lys-Thr-Lys-Val-Leu-r-Val-Val-Gln-Pro-Lys
-
bovine leukemia virus
0.088
-
Ala-Pro-Gln-Val-Leu-r-Pro-Val-Met-His-Pro
-
bovine leukemia virus
0.108
-
Lys-Thr-Lys-Val-Sta-Val-Gln-Pro-Gly
-
bovine leukemia virus
0.114
-
amprenavir
-
bovine leukemia virus
0.181
-
Ala-Pro-Gln-Val-Sta-Val-Met-His-Pro
-
bovine leukemia virus
1
-
HBY-793
a compound which inhibits EIAV PR
bovine leukemia virus
1.715
-
KH 164
modest inhibitor of MMLV PR
bovine leukemia virus
9.475
-
indinavir
-
bovine leukemia virus
11.47
-
ritonavir
-
bovine leukemia virus
12.96
-
LP-149
inhibitor of FIV PR
bovine leukemia virus
20
-
DMP-323
value above 20 mM
bovine leukemia virus
20
-
nelfinavir
value above 20 mM
bovine leukemia virus
20
-
saquinavir
value above 20 mM
bovine leukemia virus
20
-
UK 88.947
a compound which inhibits HIV-1PR
bovine leukemia virus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
DTT
assay with
bovine leukemia virus
EDTA
assay with
bovine leukemia virus
Engineering (protein specific)
Protein Variants
Commentary
Organism
N38D
Km: 0.18 mM (KTKVLVVQPK), kcat: 0.023/sec (KTKVLVVQPK)
bovine leukemia virus
V57I
Km: 0.0075 mM (KTKVLVVQPK), kcat: 0.006/sec (KTKVLVVQPK)
bovine leukemia virus
V57I/L58G/A60I
Km: 0.03 mM (KTKVLVVQPK), kcat: 0.016/sec (KTKVLVVQPK)
bovine leukemia virus
W99V
Km: 0.006 mM (KTKVLVVQPK), kcat: 0.003/sec (KTKVLVVQPK)
bovine leukemia virus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Ala-Pro-Gln-Val-Leu-r-Pro-Val-Met-His-Pro
-
bovine leukemia virus
Ala-Pro-Gln-Val-Sta-Val-Met-His-Pro
-
bovine leukemia virus
amprenavir
-
bovine leukemia virus
DMP-323
-
bovine leukemia virus
HBY-793
a compound which inhibits EIAV PR
bovine leukemia virus
indinavir
-
bovine leukemia virus
KH 164
modest inhibitor of MMLV PR
bovine leukemia virus
LP-149
inhibitor of FIV PR
bovine leukemia virus
Lys-Thr-Lys-Val-Leu-r-Val-Val-Gln-Pro-Lys
-
bovine leukemia virus
Lys-Thr-Lys-Val-Sta-Val-Gln-Pro-Gly
-
bovine leukemia virus
nelfinavir
-
bovine leukemia virus
ritonavir
-
bovine leukemia virus
saquinavir
-
bovine leukemia virus
UK 88.947
a compound which inhibits HIV-1PR
bovine leukemia virus
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.013
-
Lys-Thr-Lys-Val-Leu-r-Val-Val-Gln-Pro-Lys
-
bovine leukemia virus
0.088
-
Ala-Pro-Gln-Val-Leu-r-Pro-Val-Met-His-Pro
-
bovine leukemia virus
0.108
-
Lys-Thr-Lys-Val-Sta-Val-Gln-Pro-Gly
-
bovine leukemia virus
0.114
-
amprenavir
-
bovine leukemia virus
0.181
-
Ala-Pro-Gln-Val-Sta-Val-Met-His-Pro
-
bovine leukemia virus
1
-
HBY-793
a compound which inhibits EIAV PR
bovine leukemia virus
1.715
-
KH 164
modest inhibitor of MMLV PR
bovine leukemia virus
9.475
-
indinavir
-
bovine leukemia virus
11.47
-
ritonavir
-
bovine leukemia virus
12.96
-
LP-149
inhibitor of FIV PR
bovine leukemia virus
20
-
DMP-323
value above 20 mM
bovine leukemia virus
20
-
nelfinavir
value above 20 mM
bovine leukemia virus
20
-
saquinavir
value above 20 mM
bovine leukemia virus
20
-
UK 88.947
a compound which inhibits HIV-1PR
bovine leukemia virus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.006
-
KTKVLVVQPK
value below 0.006, mutant W99V
bovine leukemia virus
0.0075
-
KTKVLVVQPK
mutant V57I
bovine leukemia virus
0.01
-
KPKVLVVQPK
value below 0.01, P4-substituted peptide
bovine leukemia virus
0.01
-
KTAVLVVQPK
value below 0.01, P3-substituted peptide
bovine leukemia virus
0.01
-
KTKILVVQPK
value below 0.01, P2-substituted peptide
bovine leukemia virus
0.01
-
KTKVAVVQPK
P1-substituted peptide
bovine leukemia virus
0.01
-
KTKVGVVQPK
value below 0.01, P1-substituted peptide
bovine leukemia virus
0.01
-
KTKVLFVQPK
value below 0.01, P1'-substituted peptide
bovine leukemia virus
0.01
-
KTLVLVVQPK
value below 0.01, P3-substituted peptide
bovine leukemia virus
0.01
-
KTSVLVVQPK
value below 0.01, P3-substituted peptide
bovine leukemia virus
0.01
-
KTVVLVVQPK
value below 0.01, P3-substituted peptide
bovine leukemia virus
0.01
-
KVKVLVVQPK
value below 0.01, P4-substituted peptide
bovine leukemia virus
0.01
-
TKVLVVQPK
-
bovine leukemia virus
0.011
-
KTKVLVVQPK
-
bovine leukemia virus
0.014
-
KTKVYVVQPK
P1-substituted peptide
bovine leukemia virus
0.015
-
KVLVVQPK
-
bovine leukemia virus
0.016
-
KTKVLSVQPK
P1'-substituted peptide
bovine leukemia virus
0.017
-
KTKVSVVQPK
P1-substituted peptide
bovine leukemia virus
0.02
-
KTGVLVVQPK
value below 0.02, P3-substituted peptide
bovine leukemia virus
0.02
-
KTKALVVQPK
value below 0.02, P2-substituted peptide
bovine leukemia virus
0.02
-
KTKFLVVQPK
value below 0.02, P2-substituted peptide
bovine leukemia virus
0.02
-
KTKVMVVQPK
value below 0.02, P1-substituted peptide
bovine leukemia virus
0.021
-
KGKVLVVQPK
P4-substituted peptide
bovine leukemia virus
0.021
-
KTKVLGVQPK
P1'-substituted peptide
bovine leukemia virus
0.021
-
KTKVLIVQPK
P1'-substituted peptide
bovine leukemia virus
0.021
-
KTKVLLVQPK
P1'-substituted peptide
bovine leukemia virus
0.022
-
KSKVLVVQPK
P4-substitutedpeptide
bovine leukemia virus
0.025
-
KTKLLVVQPK
P2-substituted peptide
bovine leukemia virus
0.026
-
KTDVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.026
-
KTKSLVVQPK
P2-substituted peptide
bovine leukemia virus
0.03
-
KLKVLVVQPK
value below 0.03, P4-substituted peptide
bovine leukemia virus
0.03
-
KTKVLVVQPK
mutant D97T/K98P/W99V
bovine leukemia virus
0.032
-
KTKVDVVQPK
P1-substituted peptide
bovine leukemia virus
0.033
-
KTKNLVVQPK
P2-substituted peptide
bovine leukemia virus
0.042
-
KAKVLVVQPK
P4-substitutedpeptide
bovine leukemia virus
0.042
-
KTFVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.043
-
KTKDLVVQPK
P2-substituted peptide
bovine leukemia virus
0.048
-
KDKVLVVQPK
P4-substitutedpeptide
bovine leukemia virus
0.048
-
KTKVFVVQPK
P1-substituted peptide
bovine leukemia virus
0.063
-
KTKVLPVQPK
P1'-substituted peptide
bovine leukemia virus
0.13
-
KTKVLKVQPK
P1'-substituted peptide
bovine leukemia virus
0.18
-
KTKVLVVQPK
mutant N38D
bovine leukemia virus
0.2
-
KTKGLVVQPK
P2-substituted peptide
bovine leukemia virus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
KAKVLVVQPK + H2O
P4-substituted peptide
681171
bovine leukemia virus
KAKVL + VVQPK
-
-
-
?
KDKVLVVQPK + H2O
P4-substituted peptide
681171
bovine leukemia virus
KDKVL + VVQPK
-
-
-
?
KGKVLVVQPK + H2O
P4-substituted peptide
681171
bovine leukemia virus
KGKVL + VVQPK
-
-
-
?
KLKVLVVQPK + H2O
P4-substituted peptide
681171
bovine leukemia virus
KLKVL + VVQPK
-
-
-
?
KPKVLVVQPK + H2O
P4-substituted peptide
681171
bovine leukemia virus
KPKVL + VVQPK
-
-
-
?
KSKVLVVQPK + H2O
P4-substituted peptide
681171
bovine leukemia virus
KSKVL + VVQPK
-
-
-
?
KTAVLVVQPK + H2O
P3-substituted peptide
681171
bovine leukemia virus
KTGVL + VVQPK
-
-
-
?
KTDVLVVQPK + H2O
P3-substituted peptide
681171
bovine leukemia virus
KTDVL + VVQPK
-
-
-
?
KTFVLVVQPK + H2O
P3-substituted peptide
681171
bovine leukemia virus
KTFVL + VVQPK
-
-
-
?
KTGVLVVQPK + H2O
P3-substituted peptide
681171
bovine leukemia virus
KTGVL + VVQPK
-
-
-
?
KTKALVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKAL + VVQPK
-
-
-
?
KTKDLVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKDL + VVQPK
-
-
-
?
KTKFLVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKFL + VVQPK
-
-
-
?
KTKGLVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKGL + VVQPK
-
-
-
?
KTKILVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKIL + VVQPK
-
-
-
?
KTKLLVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKLL + VVQPK
-
-
-
?
KTKNLVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKNL + VVQPK
-
-
-
?
KTKSLVVQPK + H2O
P2-substituted peptide
681171
bovine leukemia virus
KTKSL + VVQPK
-
-
-
?
KTKVAVVQPK + H2O
P1-substituted peptide
681171
bovine leukemia virus
KTKVA + VVQPK
-
-
-
?
KTKVDVVQPK + H2O
P1-substituted peptide
681171
bovine leukemia virus
KTKVD + VVQPK
-
-
-
?
KTKVFVVQPK + H2O
P1-substituted peptide
681171
bovine leukemia virus
KTKVF + VVQPK
-
-
-
?
KTKVGVVQPK + H2O
P1-substituted peptide
681171
bovine leukemia virus
KTKVG + VVQPK
-
-
-
?
KTKVLDVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + DVQPK
-
-
-
?
KTKVLFVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + FVQPK
-
-
-
?
KTKVLGVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + GVQPK
-
-
-
?
KTKVLIVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + IVQPK
-
-
-
?
KTKVLKVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + KVQPK
-
-
-
?
KTKVLLVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + LVQPK
-
-
-
?
KTKVLPVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + PVQPK
-
-
-
?
KTKVLSVQPK + H2O
P1'-substituted peptide
681171
bovine leukemia virus
KTKVL + SVQPK
-
-
-
?
KTKVLVVQPK + H2O
-
681171
bovine leukemia virus
KTKVL + VVQPK
-
-
-
?
KTKVMVVQPK + H2O
P1-substituted peptide
681171
bovine leukemia virus
KTKVM + VVQPK
-
-
-
?
KTKVSVVQPK + H2O
P1-substituted peptide
681171
bovine leukemia virus
KTKVS + VVQPK
-
-
-
?
KTKVYVVQPK + H2O
P1-substituted peptide
681171
bovine leukemia virus
KTKVY + VVQPK
-
-
-
?
KTLVLVVQPK + H2O
P3-substituted peptide
681171
bovine leukemia virus
KTLVL + VVQPK
-
-
-
?
KTSVLVVQPK + H2O
P3-substituted peptide
681171
bovine leukemia virus
KTSVL + VVQPK
-
-
-
?
KTVVLVVQPK + H2O
P3-substituted peptide
681171
bovine leukemia virus
KTVVL + VVQPK
-
-
-
?
KVKVLVVQPK + H2O
P4-substituted peptide
681171
bovine leukemia virus
KVKVL + VVQPK
-
-
-
?
KVLVVQPK + H2O
-
681171
bovine leukemia virus
KVL + VVQPK
-
-
-
?
TKVLVVQPK + H2O
-
681171
bovine leukemia virus
TKVL + VVQPK
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
bovine leukemia virus
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.003
-
KTKVLVVQPK
mutant W99V
bovine leukemia virus
0.006
-
KTKVLVVQPK
mutant V57I
bovine leukemia virus
0.01
-
KTKVLDVQPK
value below 0.01, P1'-substituted peptide
bovine leukemia virus
0.016
-
KTKVLVVQPK
mutant D97T/K98P/W99V
bovine leukemia virus
0.07
-
KTKDLVVQPK
P2-substituted peptide
bovine leukemia virus
0.09
-
KTKVGVVQPK
P1-substituted peptide
bovine leukemia virus
0.11
-
KTKVDVVQPK
P1-substituted peptide
bovine leukemia virus
0.11
-
KTKVSVVQPK
P1-substituted peptide
bovine leukemia virus
0.11
-
KTLVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.12
-
KTKVLGVQPK
P1'-substituted peptide
bovine leukemia virus
0.13
-
KTKNLVVQPK
P2-substituted peptide
bovine leukemia virus
0.13
-
KTVVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.16
-
KPKVLVVQPK
P4-substituted peptide
bovine leukemia virus
0.17
-
KTDVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.18
-
KTAVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.18
-
KTKVLSVQPK
P1'-substituted peptide
bovine leukemia virus
0.19
-
KSKVLVVQPK
P4-substituted peptide
bovine leukemia virus
0.19
-
KTKGLVVQPK
P2-substituted peptide
bovine leukemia virus
0.2
-
KTSVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.2
-
KVKVLVVQPK
P4-substituted peptide
bovine leukemia virus
0.22
-
KAKVLVVQPK
P4-substituted peptide
bovine leukemia virus
0.23
-
KTKVLIVQPK
P1'-substituted peptide
bovine leukemia virus
0.23
-
KTKVLVVQPK
mutant N38D
bovine leukemia virus
0.24
-
KTKVMVVQPK
P1-substituted peptide
bovine leukemia virus
0.27
-
KTKVLVVQPK
-
bovine leukemia virus
0.28
-
KTKVLFVQPK
P1'-substituted peptide
bovine leukemia virus
0.29
-
KTKILVVQPK
P2-substituted peptide
bovine leukemia virus
0.29
-
KTKLLVVQPK
P2-substituted peptide
bovine leukemia virus
0.32
-
KTKFLVVQPK
P2-substituted peptide
bovine leukemia virus
0.34
-
KTKVAVVQPK
P1-substituted peptide
bovine leukemia virus
0.34
-
KTKVLLVQPK
P1'-substituted peptide
bovine leukemia virus
0.35
-
KTKALVVQPK
P2-substituted peptide
bovine leukemia virus
0.35
-
KTKSLVVQPK
P2-substituted peptide
bovine leukemia virus
0.35
-
TKVLVVQPK
-
bovine leukemia virus
0.36
-
KTKVLKVQPK
P1'-substituted peptide
bovine leukemia virus
0.44
-
KTFVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.58
-
KGKVLVVQPK
P4-substituted peptide
bovine leukemia virus
0.71
-
KVLVVQPK
-
bovine leukemia virus
0.74
-
KLKVLVVQPK
P4-substituted peptide
bovine leukemia virus
0.74
-
KTGVLVVQPK
P3-substituted peptide
bovine leukemia virus
0.74
-
KTKVYVVQPK
P1-substituted peptide
bovine leukemia virus
0.85
-
KTKVLPVQPK
P1'-substituted peptide
bovine leukemia virus
0.9
-
KDKVLVVQPK
P4-substituted peptide
bovine leukemia virus
2
-
KTKVFVVQPK
P1-substituted peptide
bovine leukemia virus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.6
-
assay at
bovine leukemia virus
Other publictions for EC 3.4.23.B9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
693905
Eizert
Amino acid preferences of retr ...
bovine leukemia virus
J. Virol.
82
10111-10117
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681171
Sperka
Bovine leukemia virus protease ...
bovine leukemia virus
J. Gen. Virol.
88
2052-2063
2007
2
-
-
-
4
-
14
43
-
-
-
-
-
6
-
-
-
-
-
-
-
-
40
-
2
1
-
-
44
1
-
-
-
14
-
-
2
-
-
-
-
4
-
-
14
14
43
-
-
-
-
-
-
-
-
-
-
-
-
40
-
1
-
-
44
1
-
-
-
-
-
-
-
-
-
666190
Bagossi
Amino acid preferences for a c ...
bovine leukemia virus
J. Virol.
79
4213-4218
2005
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
10
1
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
10
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
668796
Menard
-
Bovine leukemia virus retropep ...
bovine leukemia virus, bovine leukemia virus BLV
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. )
1
169-171
2004
-
-
1
-
-
-
8
-
-
2
1
4
-
2
-
1
1
1
-
-
-
-
10
1
4
1
1
-
-
1
1
1
-
-
1
7
-
-
1
-
-
-
-
7
8
-
-
-
2
1
4
-
-
1
1
-
-
-
-
10
1
1
1
-
-
1
1
1
1
-
-
-
-
-
-
647867
Zahuczky
Cloning of the bovine leukemia ...
bovine leukemia virus
Biochim. Biophys. Acta
1478
1-8
2000
-
-
1
-
-
-
-
2
1
-
-
-
-
1
-
-
1
-
-
-
-
-
6
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
1
-
-
-
-
6
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
647864
Menard
Inhibition of activity of the ...
bovine leukemia virus
FEBS Lett.
346
268-272
1994
-
-
-
-
-
-
5
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
5
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
647865
Precigoux
Modelling, synthesis and biolo ...
bovine leukemia virus
FEBS Lett.
326
237-240
1993
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
647866
Menard
Bovine leukemia virus: purific ...
bovine leukemia virus
Virology
193
680-689
1993
-
-
-
-
-
-
1
-
-
2
1
-
-
3
-
-
1
-
-
-
1
-
1
1
-
1
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
2
1
-
-
-
-
1
-
-
1
-
1
1
1
1
-
-
1
1
-
-
-
-
-
-
-
-
647863
Rice N.R.; Stephens R.M.; Burny A.; Gilden R.V.
The gag and pol genes of bovin ...
bovine leukemia virus
Virology
142
357-377
1985
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-