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Literature summary for 3.4.23.B8 extracted from

  • Tatsumi, T.; Awahara, C.; Naka, H.; Aimoto, S.; Konno, H.; Nosaka, K.; Akaji, K.
    Evaluation of retro-inverso modifications of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster (2010), Bioorg. Med. Chem., 18, 2720-2727.
    View publication on PubMed
Search for more literature for 3.4.23.B8

Inhibitors

Inhibitors Comment Organism Structure
N-[(2R)-2-[(1R)-2-[(2R)-1-(benzylcarbamoyl)pyrrolidin-2-yl]-1-hydroxyethyl]-4-methylpentanoyl]-D-isoleucyl-D-valyl-D-prolyl-D-prolinamide
-
 Human T-cell leukemia virus type I
N-[(2R)-2-[(1S)-2-[(2R)-1-(benzylcarbamoyl)pyrrolidin-2-yl]-1-hydroxyethyl]-4-methylpentanoyl]-D-isoleucyl-D-valyl-D-prolyl-D-prolinamide
-
 Human T-cell leukemia virus type I
N-[(2S)-2-[(1R)-2-[(2R)-1-(benzylcarbamoyl)pyrrolidin-2-yl]-1-hydroxyethyl]-4-methylpentanoyl]-D-isoleucyl-D-valyl-D-prolyl-D-prolinamide
-
 Human T-cell leukemia virus type I
N-[(2S)-2-[(1S)-2-[(2R)-1-(benzylcarbamoyl)pyrrolidin-2-yl]-1-hydroxyethyl]-4-methylpentanoyl]-D-isoleucyl-D-valyl-D-prolyl-D-prolinamide
-
 Human T-cell leukemia virus type I
N-[(2S,3R)-3-(acetylamino)-2-hydroxy-5-methylhexyl]-D-isoleucyl-D-valyl-D-prolinamide
-
 Human T-cell leukemia virus type I
N-[(2S,3R)-3-[(1-acetyl-D-prolyl)amino]-2-hydroxy-5-methylhexyl]-D-isoleucyl-D-valyl-D-prolinamide
-
 Human T-cell leukemia virus type I

Organism

Organism UniProt Comment Textmining
Human T-cell leukemia virus type I
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
HTLV-1 protease
-
 Human T-cell leukemia virus type I

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.16
-
 in 0.5 M sodium acetate buffer, pH 5.6, containing 10% (v/v) glycerol, 10 mM dithiothretiol and 4 M NaCl, temperature not specified in the publication Human T-cell leukemia virus type I N-[(2S)-2-[(1R)-2-[(2R)-1-(benzylcarbamoyl)pyrrolidin-2-yl]-1-hydroxyethyl]-4-methylpentanoyl]-D-isoleucyl-D-valyl-D-prolyl-D-prolinamide
0.35
-
 in 0.5 M sodium acetate buffer, pH 5.6, containing 10% (v/v) glycerol, 10 mM dithiothretiol and 4 M NaCl, temperature not specified in the publication Human T-cell leukemia virus type I N-[(2R)-2-[(1R)-2-[(2R)-1-(benzylcarbamoyl)pyrrolidin-2-yl]-1-hydroxyethyl]-4-methylpentanoyl]-D-isoleucyl-D-valyl-D-prolyl-D-prolinamide
0.55
-
 in 0.5 M sodium acetate buffer, pH 5.6, containing 10% (v/v) glycerol, 10 mM dithiothretiol and 4 M NaCl, temperature not specified in the publication Human T-cell leukemia virus type I N-[(2S)-2-[(1S)-2-[(2R)-1-(benzylcarbamoyl)pyrrolidin-2-yl]-1-hydroxyethyl]-4-methylpentanoyl]-D-isoleucyl-D-valyl-D-prolyl-D-prolinamide
1.5
-
 in 0.5 M sodium acetate buffer, pH 5.6, containing 10% (v/v) glycerol, 10 mM dithiothretiol and 4 M NaCl, temperature not specified in the publication Human T-cell leukemia virus type I N-[(2R)-2-[(1S)-2-[(2R)-1-(benzylcarbamoyl)pyrrolidin-2-yl]-1-hydroxyethyl]-4-methylpentanoyl]-D-isoleucyl-D-valyl-D-prolyl-D-prolinamide
10
-
 IC50 above 10 mM, in 0.5 M sodium acetate buffer, pH 5.6, containing 10% (v/v) glycerol, 10 mM dithiothretiol and 4 M NaCl, temperature not specified in the publication Human T-cell leukemia virus type I N-[(2S,3R)-3-(acetylamino)-2-hydroxy-5-methylhexyl]-D-isoleucyl-D-valyl-D-prolinamide
10
-
 IC50 above 10 mM, in 0.5 M sodium acetate buffer, pH 5.6, containing 10% (v/v) glycerol, 10 mM dithiothretiol and 4 M NaCl, temperature not specified in the publication Human T-cell leukemia virus type I N-[(2S,3R)-3-[(1-acetyl-D-prolyl)amino]-2-hydroxy-5-methylhexyl]-D-isoleucyl-D-valyl-D-prolinamide

General Information

General Information Comment Organism
physiological function HTLV-1 protease is an aspartic protease and crucial for processing of the virus proteins Human T-cell leukemia virus type I