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Literature summary for 3.4.23.B8 extracted from

  • Shuker, S.B.; Mariani, V.L.; Herger, B.E.; Dennison, K.J.
    Understanding HTLV-I Protease (2003), Chem. Biol., 10, 373-380.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme is an attractive target for inhibitor design Human T-cell leukemia virus type I

Inhibitors

Inhibitors Comment Organism Structure
Ac-Leu-Lys-Ala-Gln-Ile-His-Phe
-
Human T-cell leukemia virus type I
Ac-Leu-Val-Phe-H
-
Human T-cell leukemia virus type I
Ac-Pro-Gln-Ile-Thr-Leu-Trp-Gln-Arg-Pro-NH2
-
Human T-cell leukemia virus type I
Ac-Ser-Leu-Asn-Phe-CH(OH)CH2NH-Pro-Ile-Val-methyl ester
-
Human T-cell leukemia virus type I
Ac-Thr-Leu-Asn-Phe
-
Human T-cell leukemia virus type I
Ac-Thr-Val-Ser-Phe-Asn-Phe
-
Human T-cell leukemia virus type I
Ala-Pro-Gln-Val-statine-Val-Met-His-Pro
-
Human T-cell leukemia virus type I
Gln-Met-Gln-Gly-Val-Leu-Tyr-Leu
-
Human T-cell leukemia virus type I
MES13-099
-
Human T-cell leukemia virus type I
additional information Ac-Thr-Ile-Nle(reduced peptide bond)-Nle-Gln-Arg; Arg-Val-Leu(reduced peptide bond)-Phe-Glu-Ala-Nle-NH2; Ser-Gln-Asn-Phe(reduced peptide bond)-Pro-Ile-Val Human T-cell leukemia virus type I
Pro-Val-Ile-Pro-Leu-Asp-Pro-Ala-Arg-Arg-Pro-Val
-
Human T-cell leukemia virus type I
tert-butyloxycarbonyl-Val-Val-Phe-Psi[P(O)(OH)]-Phe-Val-Val-NH2
-
Human T-cell leukemia virus type I
Tyr-Leu-Pro-Glu-Ala-Lys-Arg-Pro-Pro-Val-Ile-Leu
-
Human T-cell leukemia virus type I

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Human T-cell leukemia virus type I
0.014
-
PPVMGVLDAP
-
Human T-cell leukemia virus type I
0.02
-
PPAILPIISE
-
Human T-cell leukemia virus type I
0.06
-
PQVLPVMHP
-
Human T-cell leukemia virus type I
0.087
-
TKVLVVQPK
-
Human T-cell leukemia virus type I
0.23
-
DPASILPVIP
-
Human T-cell leukemia virus type I
0.5
-
YVEPTAPQVLPVMHP
-
Human T-cell leukemia virus type I

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Human T-cell leukemia virus type I the enzyme produces the mature strucrtural proteins and enzymes essential for viral replication ?
-
?

Organism

Organism UniProt Comment Textmining
Human T-cell leukemia virus type I
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
APQVLPVMHPHG + H2O
-
Human T-cell leukemia virus type I APQVL + PVMHPHG
-
?
DPASILPVIP + H2O
-
Human T-cell leukemia virus type I DPASIL + PVIP
-
?
KGPPVILPIQAP + H2O
-
Human T-cell leukemia virus type I KGPPVIL + PIQAP
-
?
KQPAILVHTPG + H2O
-
Human T-cell leukemia virus type I KQPAIL + VHTPG
-
?
KTKVLVVQPK + H2O
-
Human T-cell leukemia virus type I KTKVL + VVQPK
-
?
additional information the enzyme produces the mature strucrtural proteins and enzymes essential for viral replication Human T-cell leukemia virus type I ?
-
?
PPAILPIISE + H2O
-
Human T-cell leukemia virus type I PPAIL + PIISE
-
?
PPVMGVLDAP + H2O
-
Human T-cell leukemia virus type I PPVMG + VLDAP
-
?
PQVLPVMHP + H2O
-
Human T-cell leukemia virus type I PQVL + PVMHP
-
?
TKVLVVQPK + H2O
-
Human T-cell leukemia virus type I TKVL + VVQPK
-
?
VSQNYPIVQ + H2O
-
Human T-cell leukemia virus type I VSQNY + PIVQ
-
?
YVEPTAPQVLPVMHP + H2O
-
Human T-cell leukemia virus type I ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information
-
Human T-cell leukemia virus type I
0.00833
-
PPVMGVLDAP
-
Human T-cell leukemia virus type I
0.085
-
YVEPTAPQVLPVMHP
-
Human T-cell leukemia virus type I
0.22
-
PQVLPVMHP
-
Human T-cell leukemia virus type I
0.7
-
DPASILPVIP
-
Human T-cell leukemia virus type I
2.7
-
TKVLVVQPK
-
Human T-cell leukemia virus type I
3.3
-
PPAILPIISE
-
Human T-cell leukemia virus type I

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000006
-
Ac-Ser-Leu-Asn-Phe-CH(OH)CH2NH-Pro-Ile-Val-methyl ester
-
Human T-cell leukemia virus type I
0.00005
-
Ala-Pro-Gln-Val-statine-Val-Met-His-Pro
-
Human T-cell leukemia virus type I
0.00008
-
tert-butyloxycarbonyl-Val-Val-Phe[P(O)(OH)-]-Phe-Val-Val-NH2
-
Human T-cell leukemia virus type I
0.00024
-
MES13-099
-
Human T-cell leukemia virus type I
0.0057
-
Tyr-Leu-Pro-Glu-Ala-Lys-Arg-Pro-Pro-Val-Ile-Leu
-
Human T-cell leukemia virus type I
0.0506
-
Ac-Leu-Lys-Ala-Gln-Ile-His-Phe
-
Human T-cell leukemia virus type I
0.07
-
Gln-Met-Gln-Gly-Val-Leu-Tyr-Leu
-
Human T-cell leukemia virus type I
0.0872
-
Pro-Val-Ile-Pro-Leu-Asp-Pro-Ala-Arg-Arg-Pro-Val
-
Human T-cell leukemia virus type I
0.093
-
Ac-Leu-Val-Phe-H
-
Human T-cell leukemia virus type I
0.217
-
Ac-Thr-Val-Ser-Phe-Asn-Phe
-
Human T-cell leukemia virus type I
0.252
-
Ac-Thr-Leu-Asn-Phe
-
Human T-cell leukemia virus type I
1.7
-
Ac-Pro-Gln-Ile-Thr-Leu-Trp-Gln-Arg-Pro-NH2
-
Human T-cell leukemia virus type I