Application | Comment | Organism |
---|---|---|
medicine | the enzyme is an attractive target for inhibitor design | Human T-cell leukemia virus type I |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ac-Leu-Lys-Ala-Gln-Ile-His-Phe | - |
Human T-cell leukemia virus type I | |
Ac-Leu-Val-Phe-H | - |
Human T-cell leukemia virus type I | |
Ac-Pro-Gln-Ile-Thr-Leu-Trp-Gln-Arg-Pro-NH2 | - |
Human T-cell leukemia virus type I | |
Ac-Ser-Leu-Asn-Phe-CH(OH)CH2NH-Pro-Ile-Val-methyl ester | - |
Human T-cell leukemia virus type I | |
Ac-Thr-Leu-Asn-Phe | - |
Human T-cell leukemia virus type I | |
Ac-Thr-Val-Ser-Phe-Asn-Phe | - |
Human T-cell leukemia virus type I | |
Ala-Pro-Gln-Val-statine-Val-Met-His-Pro | - |
Human T-cell leukemia virus type I | |
Gln-Met-Gln-Gly-Val-Leu-Tyr-Leu | - |
Human T-cell leukemia virus type I | |
MES13-099 | - |
Human T-cell leukemia virus type I | |
additional information | Ac-Thr-Ile-Nle(reduced peptide bond)-Nle-Gln-Arg; Arg-Val-Leu(reduced peptide bond)-Phe-Glu-Ala-Nle-NH2; Ser-Gln-Asn-Phe(reduced peptide bond)-Pro-Ile-Val | Human T-cell leukemia virus type I | |
Pro-Val-Ile-Pro-Leu-Asp-Pro-Ala-Arg-Arg-Pro-Val | - |
Human T-cell leukemia virus type I | |
tert-butyloxycarbonyl-Val-Val-Phe-Psi[P(O)(OH)]-Phe-Val-Val-NH2 | - |
Human T-cell leukemia virus type I | |
Tyr-Leu-Pro-Glu-Ala-Lys-Arg-Pro-Pro-Val-Ile-Leu | - |
Human T-cell leukemia virus type I |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Human T-cell leukemia virus type I | |
0.014 | - |
PPVMGVLDAP | - |
Human T-cell leukemia virus type I | |
0.02 | - |
PPAILPIISE | - |
Human T-cell leukemia virus type I | |
0.06 | - |
PQVLPVMHP | - |
Human T-cell leukemia virus type I | |
0.087 | - |
TKVLVVQPK | - |
Human T-cell leukemia virus type I | |
0.23 | - |
DPASILPVIP | - |
Human T-cell leukemia virus type I | |
0.5 | - |
YVEPTAPQVLPVMHP | - |
Human T-cell leukemia virus type I |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Human T-cell leukemia virus type I | the enzyme produces the mature strucrtural proteins and enzymes essential for viral replication | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human T-cell leukemia virus type I | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
APQVLPVMHPHG + H2O | - |
Human T-cell leukemia virus type I | APQVL + PVMHPHG | - |
? | |
DPASILPVIP + H2O | - |
Human T-cell leukemia virus type I | DPASIL + PVIP | - |
? | |
KGPPVILPIQAP + H2O | - |
Human T-cell leukemia virus type I | KGPPVIL + PIQAP | - |
? | |
KQPAILVHTPG + H2O | - |
Human T-cell leukemia virus type I | KQPAIL + VHTPG | - |
? | |
KTKVLVVQPK + H2O | - |
Human T-cell leukemia virus type I | KTKVL + VVQPK | - |
? | |
additional information | the enzyme produces the mature strucrtural proteins and enzymes essential for viral replication | Human T-cell leukemia virus type I | ? | - |
? | |
PPAILPIISE + H2O | - |
Human T-cell leukemia virus type I | PPAIL + PIISE | - |
? | |
PPVMGVLDAP + H2O | - |
Human T-cell leukemia virus type I | PPVMG + VLDAP | - |
? | |
PQVLPVMHP + H2O | - |
Human T-cell leukemia virus type I | PQVL + PVMHP | - |
? | |
TKVLVVQPK + H2O | - |
Human T-cell leukemia virus type I | TKVL + VVQPK | - |
? | |
VSQNYPIVQ + H2O | - |
Human T-cell leukemia virus type I | VSQNY + PIVQ | - |
? | |
YVEPTAPQVLPVMHP + H2O | - |
Human T-cell leukemia virus type I | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Human T-cell leukemia virus type I | |
0.00833 | - |
PPVMGVLDAP | - |
Human T-cell leukemia virus type I | |
0.085 | - |
YVEPTAPQVLPVMHP | - |
Human T-cell leukemia virus type I | |
0.22 | - |
PQVLPVMHP | - |
Human T-cell leukemia virus type I | |
0.7 | - |
DPASILPVIP | - |
Human T-cell leukemia virus type I | |
2.7 | - |
TKVLVVQPK | - |
Human T-cell leukemia virus type I | |
3.3 | - |
PPAILPIISE | - |
Human T-cell leukemia virus type I |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000006 | - |
Ac-Ser-Leu-Asn-Phe-CH(OH)CH2NH-Pro-Ile-Val-methyl ester | - |
Human T-cell leukemia virus type I | |
0.00005 | - |
Ala-Pro-Gln-Val-statine-Val-Met-His-Pro | - |
Human T-cell leukemia virus type I | |
0.00008 | - |
tert-butyloxycarbonyl-Val-Val-Phe[P(O)(OH)-]-Phe-Val-Val-NH2 | - |
Human T-cell leukemia virus type I | |
0.00024 | - |
MES13-099 | - |
Human T-cell leukemia virus type I | |
0.0057 | - |
Tyr-Leu-Pro-Glu-Ala-Lys-Arg-Pro-Pro-Val-Ile-Leu | - |
Human T-cell leukemia virus type I | |
0.0506 | - |
Ac-Leu-Lys-Ala-Gln-Ile-His-Phe | - |
Human T-cell leukemia virus type I | |
0.07 | - |
Gln-Met-Gln-Gly-Val-Leu-Tyr-Leu | - |
Human T-cell leukemia virus type I | |
0.0872 | - |
Pro-Val-Ile-Pro-Leu-Asp-Pro-Ala-Arg-Arg-Pro-Val | - |
Human T-cell leukemia virus type I | |
0.093 | - |
Ac-Leu-Val-Phe-H | - |
Human T-cell leukemia virus type I | |
0.217 | - |
Ac-Thr-Val-Ser-Phe-Asn-Phe | - |
Human T-cell leukemia virus type I | |
0.252 | - |
Ac-Thr-Leu-Asn-Phe | - |
Human T-cell leukemia virus type I | |
1.7 | - |
Ac-Pro-Gln-Ile-Thr-Leu-Trp-Gln-Arg-Pro-NH2 | - |
Human T-cell leukemia virus type I |