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Literature summary for 3.4.23.B8 extracted from

  • Louis, J.M.; Oroszlan, S.; Tozser, J.
    Stabilization from autoproteolysis and kinetic characterization of the human T-cell leukemia virus type 1 proteinase (1999), J. Biol. Chem., 274, 6660-6666.
    View publication on PubMed
Search for more literature for 3.4.23.B8

Inhibitors

Inhibitors Comment Organism Structure
4-[(anilinocarbonyl)amino]-6-chlorobenzene-1,3-disulfonamide
-
 Human T-cell leukemia virus type I
Ala-Pro-Gln-Val-statine-Val-Met-His-Pro
-
 Human T-cell leukemia virus type I
additional information several inhibitors of HIV-1 or other retrovitral proteinases are tested on HTLV-1 proteinase, only two inhibit with a Ki-value lower than 100 nM Human T-cell leukemia virus type I

Organism

Organism UniProt Comment Textmining
Human T-cell leukemia virus type I
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Human T-cell leukemia virus type I

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
APQVLPVMHP + H2O
-
 Human T-cell leukemia virus type I APQVL + PVMHP
-
 ?
DPASILPVIP + H2O
-
 Human T-cell leukemia virus type I DPASIL + PVIP
-
 ?
KGPPVILPIQAP + H2O
-
 Human T-cell leukemia virus type I KGPPVIL + PIQAP
-
 ?
KTKVLVVQPK + H2O
-
 Human T-cell leukemia virus type I KTKVL + VVQPK
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00005
-
 Ala-Pro-Gln-Val-statine-Val-Met-His-Pro pH 5.6, 37°C Human T-cell leukemia virus type I
0.00008
-
 4-[(anilinocarbonyl)amino]-6-chlorobenzene-1,3-disulfonamide pH 5.6, 37°C Human T-cell leukemia virus type I