Literature summary for 3.4.23.B4 extracted from

Lin, Y.C.; Torbett, B.E.; Elder, J.H.
Generation of infectious feline immunodeficiency virus (FIV) encoding FIV/human immunodeficiency virus chimeric protease (2010), J. Virol., 84, 6799-6809.

Search for more literature for 3.4.23.B4

Protein Variants

Protein Variants	Comment	Organism
I37V	mutation near the active core	feline immunodeficiency virus
I37V/N55M/V59I/I98P/Q99V/P100N	the mutant shows low-level infectivity ex vivo, and after passage, progeny that exhibits a higher growth rate emerged. The mutant enzyme is sensitive to the HIV-1 PR inhibitors lopinavir and darunavir, as well as to the broad-based inhibitor TL-3	feline immunodeficiency virus
I98P	the mutant shows low-level infectivity	feline immunodeficiency virus
L97T	in addition to poor/delayed cleavage at the FIV NC-p2 junction, inefficient processing at the FIV matrix-capsid cleavage junction by the L97T mutant is also observed	feline immunodeficiency virus
M56I	the mutant cleaves the FIV nucleocapsid-p2 site poorly	feline immunodeficiency virus
N55M	the mutant gives processing patterns essentially identical to that of wild type enzyme	feline immunodeficiency virus
P100N	the mutant shows low-level infectivity	feline immunodeficiency virus
Q99V	the mutant shows low-level infectivity	feline immunodeficiency virus
V59I	the mutant gives processing patterns essentially identical to that of wild type enzyme	feline immunodeficiency virus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Gag-Pol polyprotein + H2O	feline immunodeficiency virus	FIV PR cleaves Gag polyprotein into 5 individual proteins, including matrix, capsid, p1, nucleocapsid, and p2	?	-	?

Organism

Organism	UniProt	Comment	Textmining
feline immunodeficiency virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ala-Leu-Thr-(4-aminobenzoic acid)-Lys-Val-Gln-p-NO2-Phe-Val-Gln-Ser-Lys-Gly + H2O	-	feline immunodeficiency virus	Ala-Leu-Thr-(4-aminobenzoic acid)-Lys-Val-Gln + p-NO2-Phe-Val-Gln-Ser-Lys-Gly	-	?
Gag-Pol polyprotein + H2O	FIV PR cleaves Gag polyprotein into 5 individual proteins, including matrix, capsid, p1, nucleocapsid, and p2	feline immunodeficiency virus	?	-	?

Subunits

Subunits	Comment	Organism
homodimer	-	feline immunodeficiency virus

Synonyms

Synonyms	Comment	Organism
FIV PR	-	feline immunodeficiency virus
FIV protease	-	feline immunodeficiency virus

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Release 2023.1 (January 2023)