Literature summary for 3.4.23.B4 extracted from

Li, M.; Morris, G.M.; Lee, T.; Laco, G.S.; Wong, C.H.; Olson, A.J.; Elder, J.H.; Wlodawer, A.; Gustchina, A.
Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease (2000), Proteins, 38, 29-40.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
wild-type and mutant enzymes V59I and Q99V are cocrystallized with the C2-symmetric inhibitor TL-3, which contains (1S,2R,3R,4S)-1,4-diamino-1,4-dibenzyl-2,3-diol as the P1-P1' unit and Ala at P3/P3' positions	feline immunodeficiency virus

Protein Variants

Protein Variants	Comment	Organism
Q99V	mutant enzyme shows decreased inhibition constant with C2-symmetric inhibitor TL-3 compared to wild-type enzyme	feline immunodeficiency virus
V59I	mutant enzyme shows decreased inhibition constant with C2-symmetric inhibitor TL-3 compared to wild-type enzyme	feline immunodeficiency virus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	C2-symmetric inhibitor TL-3, which contains (1S,2R,3R,4S)-1,4-diamino-1,4-dibenzyl-2,3-diol as the P1-P1' unit and Ala at p3/p3' positions	feline immunodeficiency virus

Organism

Organism	UniProt	Comment	Textmining
feline immunodeficiency virus	-	-	-

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Release 2023.1 (January 2023)