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Literature summary for 3.4.23.B24 extracted from

  • Papadopoulou, A.A.; Mueller, S.A.; Mentrup, T.; Shmueli, M.D.; Niemeyer, J.; Haug-Kroeper, M.; von Blume, J.; Mayerhofer, A.; Feederle, R.; Schroeder, B.; Lichtenthaler, S.F.; Fluhrer, R.
    Signal peptide peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins (2019), EMBO Rep., 20, e46451.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.B24

Cloned(Commentary)

Cloned (Comment) Organism
functional ectopic overexpressing wild-type SPPL2c and catalytically inactive SPPL2c in HEK-293 cells, induction of SPPL2c overexpression with doxycycline. Neither SPP monomer nor SPP dimer is change in SPPL2c-expressing cells compared to control cells. Endogenous SPP expression is not affected by SPPL2c overexpression. Endoplasmic reticulum and Golgi morphology in HEK-293 cells with ectopic expression of SPPL2c, overview Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information proteolytic processing by SPPL2c impairs vesicular transport and causes retention of cargo proteins in the endoplasmic reticulum in recombinant SPPL2c-overexpessing HEK-293 cells. As a consequence, the integrity of subcellular compartments, in particular the Golgi, is disturbed. Quantification of pre-acrosomal structures in seminiferous tubular cross sections in wild-type and SPPL2c-lacking cells Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus A2A6C4
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Source Tissue

Source Tissue Comment Organism Textmining
epididymis
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 Mus musculus
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spermatozoon
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 Mus musculus
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testis
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 Mus musculus
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Synonyms

Synonyms Comment Organism
signal peptide peptidase-like 2C
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 Mus musculus
SPPL2c
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 Mus musculus

General Information

General Information Comment Organism
physiological function involvement of SPPL2c in acrosome formation during spermatogenesis Mus musculus