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Literature summary for 3.4.23.B24 extracted from

  • Allen, S.J.; Mott, K.R.; Matsuura, Y.; Moriishi, K.; Kousoulas, K.G.; Ghiasi, H.
    Binding of HSV-1 glycoprotein K (gK) to signal peptide peptidase (SPP) is required for virus infectivity (2014), PLoS ONE, 9, e85360.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine herpes simplex virus type 1 glycoprotein specifically binds to signal peptide peptidase SPP. SPP dominant negative mutants and shRNA against SPP significantly reduce herpes simplex virus type 1 replication in vitro. SPP also affects lysosomes and endoplasmic reticulum responses to herpes simplex virus type 1 infection Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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Homo sapiens
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Vero cell
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Homo sapiens
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