Literature summary for 3.4.23.B24 extracted from

Moss, C.X.; Brown, E.; Hamilton, A.; Van der Veken, P.; Augustyns, K.; Mottram, J.C.
An essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma brucei (2015), PLoS ONE, 10, e0123241.

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Organism

Organism	UniProt	Comment	Textmining
Trypanosoma brucei	-	-	-

Synonyms

Synonyms	Comment	Organism
SPP1	-	Trypanosoma brucei

General Information

General Information	Comment	Organism
physiological function	type-I signal peptide peptidase SPP1 is essential for parasite survival both in vitro and in vivo. Expression of catalytically inactive SPP1 is unable to rescue cells from the SPP1 depleted phenotype	Trypanosoma brucei

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Release 2023.1 (January 2023)