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Literature summary for 3.4.23.B1 extracted from
- The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity (2008), Lab. Invest., 88, 256-263.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O96009 | - |
- |
| Mus musculus | O09043 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | re-expression of napsin A in tumorigenic HEK293 kidney cell line, reduced capacity for anchorage-independent growth observed | Homo sapiens | - |
| kidney | proximal tubule, expression patterns determined by in situ hybridization | Homo sapiens | - |
| renal cell carcinoma cell | expression in only one of 29 renal cell carcinomas determined, correlation to loss of napsin A expression in high-grade lung adenocarcinomas | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
expression of napsin A determined by mRNA in situ hybridization in renal cells, tumor-suppression activity determined, mutation of one of the aspartic acid residues in the napsin A catalytic site shown to affect enzyme activity but not processing, glycosylation or intracellular localization, napsin A shown to inhibit tumor growth of transformed cells by a mechanism independent of its catalytic activity | Homo sapiens |
| additional information | - |
napsin A-expressing cells shown to form tumors in SCID mice with lower efficiency and slower onset compared to vector-transfected control cells | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | association of napsin A to tumor growth inhibition determined | Mus musculus | ? | - |
? |  |
| additional information | napsin A expression in kidney analyzed by in situ hybridization of mRNA, association to tumor growth inhibition determined | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| napsin A | - |
Homo sapiens |
| napsin A | - |
Mus musculus |
| TA02 protein | - |
Homo sapiens |
| TA02 protein | - |
Mus musculus |
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