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Literature summary for 3.4.23.B1 extracted from

  • Giller, T.; Schauer-Vukasinovic, V.
    Napsin A (2004), Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press, 1, 52-53.
No PubMed abstract available
Search for more literature for 3.4.23.B1

Application

Application Comment Organism
medicine observation that napsin A is expressed in more than 90% of primary lung adenocarcinomas but not in other malignancies shows that napsin A might be a marker for this type of carcinoma. Potential use as a marker for kidney dysfunction Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
pepstatin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
multivesicular body
-
 Homo sapiens 5771
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39000
-
 1 * 39000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pulmonary surfactant protein B + H2O Homo sapiens napsin A is involved in the post-translational processing of pulmonary surfactant protein B and C in multivesivular bodies of type II pneumocytes ?
-
 ?
pulmonary surfactant protein C + H2O Homo sapiens napsin A is involved in the post-translational processing of pulmonary surfactant protein B and C in multivesivular bodies of type II pneumocytes ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification napsin A is expressed as preproenzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
alveolar cell type II
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
lung adenocarcinoma cell primary, napsin A is expressed in more than 90% of primary lung adenocarcinomas but not in other malignancies Homo sapiens
-
spleen
-
 Homo sapiens
-
urine enzymatically active napsin A can be detected in urine of healthy individuals or in patients with transplanted kidney whose kidney function appears half to fully normal. Low activity in samples from patients with diseased kidneys Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pulmonary surfactant protein B + H2O
-
 Homo sapiens ?
-
 ?
pulmonary surfactant protein B + H2O napsin A is involved in the post-translational processing of pulmonary surfactant protein B and C in multivesivular bodies of type II pneumocytes Homo sapiens ?
-
 ?
pulmonary surfactant protein C + H2O
-
 Homo sapiens ?
-
 ?
pulmonary surfactant protein C + H2O napsin A is involved in the post-translational processing of pulmonary surfactant protein B and C in multivesivular bodies of type II pneumocytes Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 39000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
napsin A
-
 Homo sapiens
TAO2
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4 5.5
-
 Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
5 6 half-life more than 10 h Homo sapiens
7
-
 half-life is around 4 h Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000002
-
 pepstatin
-
 Homo sapiens