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Literature summary for 3.4.23.5 extracted from

  • Jancekova, B.; Ondrouskova, E.; Knopfova, L.; Smarda, J.; Benes, P.
    Enzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL (2016), Tumour Biol., 37, 10685-10696 .
    View publication on PubMed
Search for more literature for 3.4.23.5

Inhibitors

Inhibitors Comment Organism Structure
pepstatin A
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Bcl-2 protein + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 34000, mature enzyme, SDS-PAGE Homo sapiens
? x * 52000, proenzyme, SDS-PAGE Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme regulates tumor necrosis factor-related apoptosis-inducing ligand-induced cell death of MDA-MB-231 breast cancer cells Homo sapiens