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Literature summary for 3.4.23.5 extracted from

  • Houben, T.; Oligschlaeger, Y.; Hendrikx, T.; Bitorina, A.V.; Walenbergh, S.M.A.; van Gorp, P.J.; Gijbels, M.J.J.; Friedrichs, S.; Plat, J.; Schaap, F.G.; Luetjohann, D.; Hofker, M.H.; Shiri-Sverdlov, R.
    Cathepsin D regulates lipid metabolism in murine steatohepatitis (2017), Sci. Rep., 7, 3494 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
pepstatin A
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Mus musculus 5764
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Synonyms

Synonyms Comment Organism
CTSD
-
Mus musculus

General Information

General Information Comment Organism
malfunction inhibition of enzyme activity dramatically improves lipid metabolism and diminishes hepatic inflammation in non-alcoholic steatohepatitis Mus musculus
physiological function the enzyme is a key player in the development of hepatic inflammation and dyslipidemia Mus musculus