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Literature summary for 3.4.23.5 extracted from

  • Pereira, H.; Oliveira, C.S.; Castro, L.; Preto, A.; Chaves, S.R.; Corte-Real, M.
    Yeast as a tool to explore cathepsin D function (2015), Microb. Cell, 2, 225-234 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.5

Application

Application Comment Organism
medicine the enzyme is an independent prognostic marker in breast cancer associated with metastatic risk and in colorectal cancer Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
pepstatin A
-
 Homo sapiens
pepstatin A
-
 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-
lysosome
-
 Saccharomyces cerevisiae 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-

Subunits

Subunits Comment Organism
? x * 34000 + x * 14000, active enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
CatD
-
 Homo sapiens
Pep4p
-
 Saccharomyces cerevisiae
preproCatD inactive zymogen Homo sapiens
proCat proenzyme Homo sapiens
Proteinase A
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction absence of the enzyme results in increased resistance to acetic acid Saccharomyces cerevisiae
physiological function the enzyme plays a dual function in acetic acid-induced cell death depending on the genetic background Saccharomyces cerevisiae
physiological function the major function of the enzyme is its involvement in general protein degradation and turnover within the lysosomal compartment. The enzyme plays a role in limited proteolysis of proteins regulating cell growth and/or tissue homeostasis, postnatal tissue homeostasis, neuronal ceroid lipofuscinosis, wound healing, epidermal differentiation and pathological conditions such as psoriasis, proliferation and regeneration in keratinocytes, processing of proteins involved in Alzheimer disease pathogenesis, post-partum cardiomyopathy resulting in heart failure, autism pathogenesis, innate immune responses and Parkinson disease, transport of phospholipids and cholesterol, and atherosclerotic lesions associated with proenzyme release from monocyte-derived macrophages Homo sapiens