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Literature summary for 3.4.23.5 extracted from

  • Liu, J.; Yang, L.; Tian, H.; Ma, Q.
    Cathepsin D is involved in the oxygen and glucose deprivation/reperfusion-induced apoptosis of astrocytes (2016), Int. J. Mol. Med., 38, 1257-1263 .
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
Cat D
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus the enzyme expression is significantly upregulated in response to oxygen-glucose deprivation/reperfusion exposure up

General Information

General Information Comment Organism
malfunction enzyme suppression has an inhibitory effect on cell apoptosis and the expression of proapoptotic proteins Mus musculus
physiological function the enzyme is involved in the oxygen and glucose deprivation/reperfusion-induced apoptosis of astrocytes. Enzyme overexpression enhances cell apoptosis and the levels of apoptogenic proteins, including Bax and caspase-3 Mus musculus