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Literature summary for 3.4.23.5 extracted from

  • Conus, S.; Pop, C.; Snipas, S.J.; Salvesen, G.S.; Simon, H.U.
    Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis (2012), J. Biol. Chem., 287, 21142-21151.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.5

Inhibitors

Inhibitors Comment Organism Structure
pepstatin A
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-caspase-8 + H2O Homo sapiens the generation of an active caspase-8 requires both cathepsin D-mediated proteolysis and homodimerization of caspase-8 caspase-8 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl-Ala-Arg-NH2 + H2O
-
 Homo sapiens ?
-
 ?
additional information N-acetyl-IETD-7-amido-4-trifluoromethylcoumarin cannot be cleaved by cathepsin D Homo sapiens ?
-
 ?
pro-caspase-8 + H2O the generation of an active caspase-8 requires both cathepsin D-mediated proteolysis and homodimerization of caspase-8 Homo sapiens caspase-8 + ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5
-
 optimum pH for pro-cathepsin-8 cleavage Homo sapiens

General Information

General Information Comment Organism
physiological function cathepsin D-induced caspase-8 activation represents a general mechanism to induce apoptosis in the absence of death receptor activation in a variety of immune and nonimmune cells Homo sapiens