Literature summary for 3.4.23.5 extracted from

Pereira, H.; Azevedo, F.; Rego, A.; Sousa, M.J.; Chaves, S.R.; Corte-Real, M.
The protective role of yeast cathepsin D in acetic acid-induced apoptosis depends on ANT (Aac2p) but not on the voltage-dependent channel (Por1p) (2013), FEBS Lett., 587, 200-205.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Saccharomyces cerevisiae	5829	-
vacuole	-	Saccharomyces cerevisiae	5773	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-
Saccharomyces cerevisiae W303-1A	-	-	-

Synonyms

Synonyms	Comment	Organism
CatD	-	Saccharomyces cerevisiae
Pep4p	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
physiological function	the enzyme translocates from the vacuole to the cytosol during acetic acid-induced apoptosis and is required for efficient mitochondrial degradation and for increased cell survival in response to this acid. The protective role of the enzyme in acetic acid-induced apoptosis depends on its catalytic activity and is independent of the yeast voltage-dependent anion channel Por1p but dependent on AAC proteins, the yeast adenine nucleotide translocator	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)