KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0211 | - |
R[K-2,4-dinitrophenyl]LRFFLIPK[G-7-amido-4-methylcoumarin] | at pH 3.7 and 37°C | Homo sapiens | |
0.0741 | - |
[aminooxy-acetyl-K]LLVVFF[D-PEG2] | at pH 3.7 and 37°C | Homo sapiens | |
0.1933 | - |
LLVVFF | at pH 3.7 and 37°C | Homo sapiens | |
0.394 | - |
LLVVYPWTQRFF | at pH 3.7 and 37°C | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
14000 | - |
1 * 34000 + 1 * 14000, mature enzyme, SDS-PAGE | Homo sapiens |
34000 | - |
1 * 34000 + 1 * 14000, mature enzyme, SDS-PAGE | Homo sapiens |
52000 | - |
x * 52000, pro-cathepsin D, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Hemoglobin + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Hemoglobin + H2O | - |
Homo sapiens | ? | - |
? | |
LLVVFF + H2O | - |
Homo sapiens | LVVFF + VVFF + LLVVF + LVVF + VVF + Leu-Leu + Phe | - |
? | |
LLVVYPWTQRFF + H2O | cleavage occurs at the C-terminus (F-F) and the N-terminus (L-L, L-V and LL-V) | Homo sapiens | LVVYPWTQRFF + VVYPWTQRFF + LLVVYPWTQRF + LVVYPWTQRF + VVYPWTQRF + Leu-Leu + Phe | - |
? | |
additional information | does not hydrolyze KLLVVFFD | Homo sapiens | ? | - |
? | |
additional information | the proenzyme can auto activate and cleave its substrates at an acidic pH | Homo sapiens | ? | - |
? | |
R[K-2,4-dinitrophenyl]LRFFLIPK[G-7-amido-4-methylcoumarin] + H2O | - |
Homo sapiens | R[K-2,4-dinitrophenyl]LRF + FLIPK[G-7-amido-4-methylcoumarin] | - |
? | |
[aminooxy-acetyl-K]LLVVFF[D-PEG2] + H2O | the proform of cathepsin D cleaves the substrate at pH 6.5 with the same cleavage selectivity obtained with the mature form of the protease | Homo sapiens | [aminooxy-acetyl-K]LL + VVF + VVFF[D-PEG2] + F[D-PEG2] | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 52000, pro-cathepsin D, SDS-PAGE | Homo sapiens |
heterodimer | 1 * 34000 + 1 * 14000, mature enzyme, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PCD | - |
Homo sapiens |
pro-cathepsin D | - |
Homo sapiens |