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Literature summary for 3.4.23.5 extracted from

  • Menon, V.; Rao, M.
    Interactions of a low molecular weight inhibitor from Streptomyces sp. MBR04 with human cathepsin D: implications in mechanism of inactivation (2014), Appl. Biochem. Biotechnol., 174, 1705-1723.
    View publication on PubMed
Search for more literature for 3.4.23.5

Inhibitors

Inhibitors Comment Organism Structure
cathepsin D inhibitor from Streptomyces sp.MBR04 reversible, competitive, slow-tight-binding inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Hemoglobin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hemoglobin + H2O
-
 Homo sapiens ?
-
 ?
N-t-BOC-Phe-Ala-Ala-Phe(4-nitro)-Phe-Val-Leu-4-hydroxymethylpyridine ester + H2O
-
 Homo sapiens ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000032
-
 cathepsin D inhibitor from Streptomyces sp.MBR04 in 0.02M sodium citrate, pH 3.0, at 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000025
-
 in 0.02M sodium citrate, pH 3.0, at 37°C Homo sapiens cathepsin D inhibitor from Streptomyces sp.MBR04