Application | Comment | Organism |
---|---|---|
medicine | cathepsin D is a marker for the detection of cellular senescence induced by ionizing radiation of xenografted tumors | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pepstatin A | specific inhibitor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic fibroblast | - |
Homo sapiens | - |
fibroblast | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
NCI-H460 cell | - |
Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | cathepsin D is not upregulated during apoptosis induced by 300 nM taxol or 0.01 mg doxorubicin or autophagy induced by 0.01 mM tamoxifen | additional information |
Homo sapiens | senescence induced by ionizing radiation (6 Gy), 0.3 mM hydrogen peroxide or anticancer drugs (40 nM camptothecin, 0.03 mM etoposide, or 50 ng doxorubicin) is associated with up-regulation of cathepsin D | up |
General Information | Comment | Organism |
---|---|---|
physiological function | cathepsin D plays a critical role in cell proliferation | Homo sapiens |