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Literature summary for 3.4.23.5 extracted from

  • Masson, O.; Bach, A.S.; Derocq, D.; Prebois, C.; Laurent-Matha, V.; Pattingre, S.; Liaudet-Coopman, E.
    Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity? (2010), Biochimie, 92, 1635-1643.
    View publication on PubMed
Search for more literature for 3.4.23.5

Application

Application Comment Organism
medicine cathepsin D is an independent marker of poor prognosis in breast cancer as it is correlated with the incidence of clinical metastasis Homo sapiens

Protein Variants

Protein Variants Comment Organism
D231N the mutant is devoid of catalytic activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
equistatin
-
 Homo sapiens
additional information when released into the plasma, cath-D is inactivated by its interaction with alpha2-macroglobulin at a neutral pH, but not at an acidic pH. DNA fragments can inhibit cath-D proteolytic activity Homo sapiens
pepstatin A most potent polypeptide inhibitor of cath-D Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol during apoptosis, lysosomal cath-D is released into the cytosol Homo sapiens 5829
-
endosome
-
 Homo sapiens 5768
-
lysosome
-
 Homo sapiens 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
 mature enzyme Homo sapiens
52000
-
 proteolytically-inactive pro-enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast epithelial cancer cell cathepsin D is overexpressed and hyper-secreted by epithelial breast cancer cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Cath-D cleaves preferentially -Phe-Phe-,-Leu-Tyr-,-Tyr-Leu-, and -Phe-Tyr-bonds in peptide chains containing at least five amino acids at an acidic pH Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cath-D
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens cathepsin D is overexpressed and hyper-secreted by epithelial breast cancer cells up

General Information

General Information Comment Organism
physiological function Cath-D stimulates cancer cell growth in an autocrine manner, and also plays a crucial paracrine role in the tumor microenvironment by stimulating fibroblast outgrowth and tumor angiogenesis Homo sapiens