Protein Variants | Comment | Organism |
---|---|---|
additional information | cultured schistosomules of Schistosoma mansoni are exposed by square wave electroporation to double stranded RNA specific for cDNA encoding cathepsin D. RNAi-mediated reductions in transcript levels leads to phenotypic changes including significant growth retardation in vitro and suppression of aspartic protease enzyme activity. In addition, black-pigmented heme, the end point by-product of normal hemoglobin proteolysis that accumulates in the schistosome gut, is not apparent within the guts of the treated schistosomules. Their guts appear to be red in color, rather than black, apparently indicating the presence of intact rather than digested host hemoglobin | Schistosoma mansoni |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schistosoma mansoni | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-methoxycoumarin-4-acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(DNP)-Arg-amide + H2O | - |
Schistosoma mansoni | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin D | - |
Schistosoma mansoni |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Schistosoma mansoni |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
3.5 | - |
assay at | Schistosoma mansoni |