Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.23.5 extracted from

  • Haidar, B.; Kiss, R.S.; Sarov-Blat, L.; Brunet, R.; Harder, C.; McPherson, R.; Marcel, Y.L.
    Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux (2006), J. Biol. Chem., 281, 39971-39981.
    View publication on PubMed
Search for more literature for 3.4.23.5

Application

Application Comment Organism
medicine the results demonstrate an important role for CTSD in intracellular cholesterol trafficking and ABCA1-mediated efflux. Decreased CTSD expression may contribute to low plasma HDL-C levels Mus musculus
medicine the results demonstrate an important role for CTSD in intracellular cholesterol trafficking and ABCA1-mediated efflux. Decreased CTSD expression may contribute to low plasma HDL-C levels Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information blocking the expression of CTSD by small interfering RNA reduces ABCA1 expression and protein abundance in macrophages and apolipoprotein A-I-mediated lipid efflux by more than 70%. Conversely, overexpression increases both ABCA1 mRNA expression and cellular ABCA1 protein Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
pepstatin A
-
 Homo sapiens
pepstatin A blocking the activity of CTSD reduces ABCA1 expression and protein abundance in both macrophages and CHO cells and apolipoprotein A-I-mediated lipid efflux by more than 70%. Consistent with its role in the proteolytic processing of prosaposin, inactivation of CTSD function results in the accumulation of glycosphingolipid and free cholesterol in late endosomes/lysosomes. Inhibition of CTSD also causes retention of ABCA1 in lysosomal compartments, reducing its trafficking to the plasma membrane Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage comparative transcriptome analysis is carried out in cholesterol-loaded monocyte-derived macrophages from low high density lipoprotein cholesterol (HDL-C) patients and control group: expression of CTSD is reduced by 50% in monocyte-derived macrophages of low HDL subjects, most significantly those with cholesterol efflux defects but without mutation in ABCA1 groups as compared with controls Homo sapiens
-
macrophage cell line cell line J774 is used Mus musculus
-

Synonyms

Synonyms Comment Organism
cathepsin D
-
 Mus musculus
cathepsin D
-
 Homo sapiens
CTSD
-
 Mus musculus
CTSD
-
 Homo sapiens