Application | Comment | Organism |
---|---|---|
medicine | the results demonstrate an important role for CTSD in intracellular cholesterol trafficking and ABCA1-mediated efflux. Decreased CTSD expression may contribute to low plasma HDL-C levels | Mus musculus |
medicine | the results demonstrate an important role for CTSD in intracellular cholesterol trafficking and ABCA1-mediated efflux. Decreased CTSD expression may contribute to low plasma HDL-C levels | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | blocking the expression of CTSD by small interfering RNA reduces ABCA1 expression and protein abundance in macrophages and apolipoprotein A-I-mediated lipid efflux by more than 70%. Conversely, overexpression increases both ABCA1 mRNA expression and cellular ABCA1 protein | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pepstatin A | - |
Homo sapiens | |
pepstatin A | blocking the activity of CTSD reduces ABCA1 expression and protein abundance in both macrophages and CHO cells and apolipoprotein A-I-mediated lipid efflux by more than 70%. Consistent with its role in the proteolytic processing of prosaposin, inactivation of CTSD function results in the accumulation of glycosphingolipid and free cholesterol in late endosomes/lysosomes. Inhibition of CTSD also causes retention of ABCA1 in lysosomal compartments, reducing its trafficking to the plasma membrane | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | comparative transcriptome analysis is carried out in cholesterol-loaded monocyte-derived macrophages from low high density lipoprotein cholesterol (HDL-C) patients and control group: expression of CTSD is reduced by 50% in monocyte-derived macrophages of low HDL subjects, most significantly those with cholesterol efflux defects but without mutation in ABCA1 groups as compared with controls | Homo sapiens | - |
macrophage cell line | cell line J774 is used | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
cathepsin D | - |
Mus musculus |
cathepsin D | - |
Homo sapiens |
CTSD | - |
Mus musculus |
CTSD | - |
Homo sapiens |