Application | Comment | Organism |
---|---|---|
medicine | results identify the lysosome as a novel target of polyphenol resveratrol activity and demonstrate a hierarchy of the proteolytic pathways involved in its cytotoxic mechanism in which the lysosomal cathepsin D acts upstream of the cytosolic caspase activation. Any metabolic, pharmacologic or genetic conditions affecting cathepsin D expression and/or activity can reflect on the sensitivity of cancer cells to polyphenol resveratrol | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | inhibition of cathepsin D by RNA interference precludes Bax oligomerization, permeabilization of mitochondrial membrane, cytosolic translocation of cytochrome c, caspase 3 activation and polyphenol resveratrol mediated cell death in human colorectal cancer cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pepstatin A | it is shown that Pepstatin A prevents polyphenol resveratrol (RV)-mediated cytotoxicity in human colorectal cancer cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal cancer cell line | human colorectal cancer cell line DLD1 and HT29 are used | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
cathepsin D | - |
Homo sapiens |