Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.23.5 extracted from

  • Johansson, A.C.; Steen, H.; Ollinger, K.; Roberg, K.
    Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine (2003), Cell Death Differ., 10, 1253-1259.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme is a key mediator in staurosporine-induced apoptosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
pepstatin A prevents release of enzyme and cytochrome c to cytosol upon treatment with staurosporine Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol after treatment with 100 nM staurosporine for 1 h partial release of enzyme and cytochrome c to cytosol, pretreatment with pepstatin prevents and delays cell death Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast foreskin fibroblast Homo sapiens
-