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Literature summary for 3.4.23.5 extracted from
- Purification and properties of a proteolytic enzyme cathepsin D, from chicken muscle (1971), Agric. Biol. Chem., 35, 1495-1502.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| H2O2 | slight activation | Gallus gallus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| I- | - |
Gallus gallus | |
| N-bromosuccinimide | 0.05 mM, 50% inhibition | Gallus gallus | |
| potassium permanganate | 0.01 mM, 50% inhibition | Gallus gallus | |
| sodium lauryl sulfate | 0.7 mM, 50% inhibition | Gallus gallus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 36000 | - |
gel filtration | Gallus gallus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| muscle | - |
Gallus gallus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Gallus gallus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| casein + H2O | urea-denatured casein | Gallus gallus | ? | - |
? | |
| Hemoglobin + H2O | - |
Gallus gallus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 40 | - |
urea-denatured casein | Gallus gallus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | 45 | 20°C: about 25% of maximal activity, 45°C: about 60% of maximal activity | Gallus gallus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 40 | - |
pH 3.5-11, 30 min, stable | Gallus gallus |
| 55 | - |
pH 5.0, 30 min, 30% loss of activity | Gallus gallus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 3.5 | - |
urea-denatured casein | Gallus gallus |
| 3.8 | - |
hemoglobin | Gallus gallus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 3.5 | 11 | 40°C, 30 min, stable in absence of Cu2+, remarkable loss of activity in presence of Cu2+ | Gallus gallus |
| 4 | 5 | maximal stability | Gallus gallus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
potassium permanganate | - |
Gallus gallus | |
| 0.05 | - |
N-bromosuccinimide | - |
Gallus gallus | |
| 0.7 | - |
sodium lauryl sulfate | - |
Gallus gallus | |
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Release 2023.1 (January 2023)
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