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Literature summary for 3.4.23.5 extracted from

  • Bonelli, G.; Kay, J.; Tessitore, L.; Jupp, R.A.; Isidoro, C.; Norey, C.G.; Autelli, R.; Richards, A.D.; Baccino, F.M.
    Purification and properties of cathepsin D from rat Yoshida ascites hepatoma AH-130 (1988), Biol. Chem. Hoppe-Seyler, 369, 323-327.
    View publication on PubMed
Search for more literature for 3.4.23.5

Inhibitors

Inhibitors Comment Organism Structure
Ascaris inhibitor
-
 Rattus norvegicus
H-256 i.e. L-Glu-L-Pro-L-Thr-L-alpha-Glu-L-Phe-PSI[CH2-NH]-L-Phe-L-Arg Rattus norvegicus
H-261 i.e. L-His-L-His-L-Pro-L-Phe-L-His-(2S,4S,5S)-5-amino-4-hydroxy-7-methyl-2-(1-methylethyl)octanoyl-L-Ile Rattus norvegicus
isovaleryl-pepstatin
-
 Rattus norvegicus
L-363,564
-
 Rattus norvegicus
lactoyl-pepstatin
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.015
-
 Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu enzyme from liver of AH-130 hepatoma-bearing rats Rattus norvegicus
0.03
-
 Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu enzyme from normal liver Rattus norvegicus
0.04
-
 Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu enzyme from cells from AH-130 hepatoma Rattus norvegicus
0.05
-
 Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu enzyme from AH-130 hepatoma cells Rattus norvegicus
0.06
-
 Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu enzyme from normal liver Rattus norvegicus
0.07
-
 Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu enzyme from liver of AH-130 hepatoma-bearing rats Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver from normal rats and from Yoshida-ascites hepatoma AH-130 cells Rattus norvegicus
-
Yoshida AH-130 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O
-
 Rattus norvegicus Lys-Pro-Ile-Glu-Phe + (4-nitro)Phe-Arg-Leu
-
 ?
Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu + H2O
-
 Rattus norvegicus ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
25
-
 Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu enzyme from liver of AH-130 hepatoma-bearing rats Rattus norvegicus
30
-
 Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu enzyme from normal liver Rattus norvegicus
40
-
 Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu enzyme from normal liver Rattus norvegicus
50
-
 Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu enzyme from liver of AH-130 hepatoma-bearing rats Rattus norvegicus
65
-
 Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu enzyme from AH-130 hepatoma cells Rattus norvegicus
95
-
 Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu enzyme from AH-130 hepatoma cells Rattus norvegicus