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Literature summary for 3.4.23.49 extracted from

  • Samykannu, G.; Vijayababu, P.; Natarajan, J.
    Substrate specificities in Salmonella typhi outer membrane protease (PgtE) from omptin family - an in silico proteomic approach (2018), Inform. Med. Unlocked, 12, 6-13 .
No PubMed abstract available
Search for more literature for 3.4.23.49

Cloned(Commentary)

Cloned (Comment) Organism
gene pgtE, DNA and amino acid sequence determination and analysis Salmonella enterica subsp. enterica serovar Typhi

Inhibitors

Inhibitors Comment Organism Structure
amprenavir
-
 Salmonella enterica subsp. enterica serovar Typhi
atazanavir sulfate
-
 Salmonella enterica subsp. enterica serovar Typhi
Cu2+ enzyme binding study Salmonella enterica subsp. enterica serovar Typhi
darunavir
-
 Salmonella enterica subsp. enterica serovar Typhi
diisopropyl fluorophosphates
-
 Salmonella enterica subsp. enterica serovar Typhi
fosamprenavir
-
 Salmonella enterica subsp. enterica serovar Typhi
indinavir
-
 Salmonella enterica subsp. enterica serovar Typhi
Mg2+ enzyme binding study Salmonella enterica subsp. enterica serovar Typhi
additional information molecular docking study with protease inhibitors, overview. No interaction with lopinavir and tipranavir Salmonella enterica subsp. enterica serovar Typhi
nelfinavir
-
 Salmonella enterica subsp. enterica serovar Typhi
pepstatin
-
 Salmonella enterica subsp. enterica serovar Typhi
phenylmethylsulfonyl fluoride
-
 Salmonella enterica subsp. enterica serovar Typhi
ritonavir
-
 Salmonella enterica subsp. enterica serovar Typhi
saquinavir
-
 Salmonella enterica subsp. enterica serovar Typhi
Zn2+ enzyme binding study Salmonella enterica subsp. enterica serovar Typhi

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metal ion docking studies, Mg2+ has better interaction with enzyme PgtE compared to Zn2+ and Cu2+ ions Salmonella enterica subsp. enterica serovar Typhi

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhi Q8Z4Y4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information substrate specificity of PgtE, determination of cleavage sites and sequences, overview Salmonella enterica subsp. enterica serovar Typhi ?
-
 ?

Synonyms

Synonyms Comment Organism
outer membrane protease
-
 Salmonella enterica subsp. enterica serovar Typhi
PgtE
-
 Salmonella enterica subsp. enterica serovar Typhi

General Information

General Information Comment Organism
evolution the enzyme belongs to the omptin family of enzymes Salmonella enterica subsp. enterica serovar Typhi
additional information PgtE three-dimensional structure homology modelling using structure with PDB ID 1I78 as a template. Residues Glu29, Leu30, His 208, Phe 215, Glu 217 and Ala 275 occupy the active site Salmonella enterica subsp. enterica serovar Typhi