Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.23.49 extracted from

  • Thomassin, J.L.; Brannon, J.R.; Gibbs, B.F.; Gruenheid, S.; Le Moual, H.
    OmpT outer membrane proteases of enterohemorrhagic and enteropathogenic Escherichia coli contribute differently to the degradation of Human LL-37 (2012), Infect. Immun., 80, 483-492.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the different contributions of EHEC and EPEC strains OmpT to the degradation and inactivation of antimicrobial peptide LL-37 may be due to their adaptation to their respective niches within the host, the colon and small intestine, respectively, where the environmental cues and abundance of antimicrobial peptides are different Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
enterohemorrhagic Escherichia coli, EHEC
-
Escherichia coli
-
enteropathogenic Escherichia coli, EPEC
-
Escherichia coli EHEC O157:H7
-
enterohemorrhagic Escherichia coli, EHEC
-
Escherichia coli EPEC / E2348/69
-
enteropathogenic Escherichia coli, EPEC
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminobenzoyl-SLGRKIQI-K(N6-2,4-dinitrophenyl)-NH2 + H2O FRET-substrate, derived from the protein C2 of the classical complement pathway Escherichia coli 2-aminobenzoyl-SLGR + KIQI-K(N6-2,4-dinitrophenyl)-NH2
-
?
2-aminobenzoyl-SLGRKIQI-K(N6-2,4-dinitrophenyl)-NH2 + H2O FRET-substrate, derived from the protein C2 of the classical complement pathway. Poor substrate Escherichia coli 2-aminobenzoyl-SLGR + KIQI-K(N6-2,4-dinitrophenyl)-NH2
-
?
2-aminobenzoyl-SLGRKIQI-K(N6-2,4-dinitrophenyl)-NH2 + H2O FRET-substrate, derived from the protein C2 of the classical complement pathway Escherichia coli EHEC O157:H7 2-aminobenzoyl-SLGR + KIQI-K(N6-2,4-dinitrophenyl)-NH2
-
?
2-aminobenzoyl-SLGRKIQI-K(N6-2,4-dinitrophenyl)-NH2 + H2O FRET-substrate, derived from the protein C2 of the classical complement pathway. Poor substrate Escherichia coli EHEC O157:H7 2-aminobenzoyl-SLGR + KIQI-K(N6-2,4-dinitrophenyl)-NH2
-
?
2-aminobenzoyl-SLGRKIQI-K(N6-2,4-dinitrophenyl)-NH2 + H2O FRET-substrate, derived from the protein C2 of the classical complement pathway Escherichia coli EPEC / E2348/69 2-aminobenzoyl-SLGR + KIQI-K(N6-2,4-dinitrophenyl)-NH2
-
?
2-aminobenzoyl-SLGRKIQI-K(N6-2,4-dinitrophenyl)-NH2 + H2O FRET-substrate, derived from the protein C2 of the classical complement pathway. Poor substrate Escherichia coli EPEC / E2348/69 2-aminobenzoyl-SLGR + KIQI-K(N6-2,4-dinitrophenyl)-NH2
-
?
C18G + H2O synthetic alpha-helical peptide, whose sequence has been optimized for maximal antibacterial activity Escherichia coli ?
-
?
C18G + H2O synthetic alpha-helical peptide, whose sequence has been optimized for maximal antibacterial activity Escherichia coli EHEC O157:H7 ?
-
?
C18G + H2O synthetic alpha-helical peptide, whose sequence has been optimized for maximal antibacterial activity Escherichia coli EPEC / E2348/69 ?
-
?
LL-37 + H2O human antimicrobial peptide of the cathelicidin family, cleavage occurs at dibasic sites Escherichia coli ?
-
?
LL-37 + H2O human antimicrobial peptide of the cathelicidin family, cleavage occurs at dibasic sites Escherichia coli EHEC O157:H7 ?
-
?
LL-37 + H2O human antimicrobial peptide of the cathelicidin family, cleavage occurs at dibasic sites Escherichia coli EPEC / E2348/69 ?
-
?

Expression

Organism Comment Expression
Escherichia coli expression of the ompT gene is higher in EHEC strains than in EPEC strains additional information

General Information

General Information Comment Organism
physiological function deletion mutant is more susceptible to alpha-helical antimicrobial peptides Escherichia coli