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Literature summary for 3.4.23.48 extracted from

  • Lathem, W.W.; Price, P.A.; Miller, V.L.; Goldman, W.E.
    A plasminogen-activating protease specifically controls the development of primary pneumonic plague (2007), Science, 315, 509-513.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
tetracycline-responsive promoter system in Yersinia pestis applied to control primary pneumonic plague progression after activation/inhibition of plasminogen activator Pla expression Yersinia pestis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Yersinia pestis
-
plasmin + ?
-
?

Organism

Organism UniProt Comment Textmining
Yersinia pestis P17811 wild-type strain CO92, isogenic strain lacking Pla (CO92 DELTA-pla) and complemented CO92 DELTA-pla strain
-

Source Tissue

Source Tissue Comment Organism Textmining
lung C57BL/6 mice infected with Yersinia pestis Yersinia pestis
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
kinetics of infection summarized, lack of plasminogen activator Pla shown to delay the time to death resulting from respiratory infection of mice, plasminogen activator Pla shown to control proliferation of Yersinia pestis in the lungs but is not essential for bacteria to disseminate, aborted inflammation and activated lung repair shown in absence of expression of plasminogen activator Pla Yersinia pestis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
Yersinia pestis plasmin + ?
-
?
plasminogen + H2O plasminogen activator Pla shown to be essential to cause primary pneumonic plague, minor importance determined for dissemination during pneumonic plague than during bubonic plague, inhibition of plasminogen activator Pla expression shown to prolong survival of infected mice Yersinia pestis plasmin + ?
-
?

Synonyms

Synonyms Comment Organism
plasminogen activator Pla
-
Yersinia pestis