Application | Comment | Organism |
---|---|---|
medicine | potential target for chemotherapy of virus infection and associated diseases, essential for maturation of infectious virions, development of drugs against the protease should be effective against HIV-2 | Human immunodeficiency virus 2 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CTLNF-PSI[CH2-NH]-PISP | competitive inhibition | Human immunodeficiency virus 2 | |
VSFNF-PSI[CH2-NH]-PQITL | competitive inhibition | Human immunodeficiency virus 2 |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.005 | - |
IRKILFLDG | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.02 | - |
MSLNLPVAKV | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.03 | - |
KARVL-AEAMS | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.06 | - |
CTLNFPISP | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.07 | - |
IPFAA-AQQRK | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.07 | - |
RGLAAPQFSL | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.08 | - |
KARLM AEALK | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.08 | - |
L-threonyl-L-alanyl-L-threonyl-L-isoleucyl-L-methionyl-L-methionyl-L-glutaminyl-L-arginylglycyl-L-asparagine | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.18 | - |
VSQNYPIVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.3 | - |
RPQNFLQSRP | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.42 | - |
DKELYPLTSL | pH 5.6, 37°C | Human immunodeficiency virus 2 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GAG precursor protein of HIV-2 + H2O | Human immunodeficiency virus 2 | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 2 | - |
human immunodeficiency virus type 2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
AETFYVDGAA + H2O | - |
Human immunodeficiency virus 2 | AETF + YVDGAA | - |
? | |
CTLNF + PISP + H2O | oligopeptide representing cleavage sites in HIV-1 Gag and Gag-Pol polyproteins, location of cleavage in PR/RT | Human immunodeficiency virus 2 | CTLNF + PISP | - |
? | |
CTLNFPISP + H2O | - |
Human immunodeficiency virus 2 | CTLNF + PISP | - |
? | |
DKELYPLTSL + H2O | oligopeptide representing cleavage sites in HIV-1 Gag and Gag-Pol polyproteins, location of cleavage in p6 | Human immunodeficiency virus 2 | DKELY + PLTSL | - |
? | |
EKGGNYPVQHV + H2O | oligopeptide representing cleavage sites in HIV-1 Gag and Gag-Pol polyproteins, location of cleavage in MA/CA | Human immunodeficiency virus 2 | EKGGNY + PVQHV | - |
? | |
GAG precursor protein F16 of HIV-1 + H2O | chemically synthesized aspartyl protease enzyme catalyzes specific processing of the recombinant 43-kDa protein | Human immunodeficiency virus 2 | ? | - |
? | |
GAG precursor protein of HIV-2 + H2O | - |
Human immunodeficiency virus 2 | ? | - |
? | |
IPFAAAQQRK + H2O | oligopeptide representing cleavage sites in HIV-1 Gag and Gag-Pol polyproteins, location of cleavage in X/NC | Human immunodeficiency virus 2 | IPFAA + AQQRK | - |
? | |
IRKILFLDG + H2O | oligopeptide representing cleavage sites in HIV-1 Gag and Gag-Pol polyproteins, location of cleavage in RT/IN | Human immunodeficiency virus 2 | IRKIL + FLDG | - |
? | |
KARLMAEALK + H2O | oligopeptide representing cleavage sites in HIV-1 Gag and Gag-Pol polyproteins, location of cleavage in MA/CA | Human immunodeficiency virus 2 | KARLM + AEALK | - |
? | |
KARVLAEAMS + H2O | oligopeptide representing cleavage sites in HIV-1 Gag and Gag-Pol polyproteins, location of cleavage CA/X | Human immunodeficiency virus 2 | KARVL + AEAMS | - |
? | |
KPRNFPVAQV + H2O | oligopeptide representing cleavage sites in HIV-1 Gag and Gag-Pol polyproteins, location of cleavage in NC/p6 | Human immunodeficiency virus 2 | KPRNF + PVAQV | - |
? | |
additional information | oligopeptide III VLAEAM.SQVTN, oligopeptide V TERQAN.FLGKI, oligopeptide VII ESFRSG.VETTT and oligopeptide XVI DRQAG.FLGLG are not hydrolyzed, oligopeptide IX VSFNF PQITL and oligopeptide XXI IRQVL FLEKI Km less than 0.01 mM | Human immunodeficiency virus 2 | ? | - |
? | |
MSLNLPVAKV + H2O | oligopeptide representing cleavage sites in HIV-1 Gag and Gag-Pol polyproteins, location of cleavage in TF/PR | Human immunodeficiency virus 2 | MSLNL + PVAKV | - |
? | |
RGLAAPQFSL + H2O | oligopeptide representing cleavage sites in HIV-1 Gag and Gag-Pol polyproteins, location of cleavage in TF/PR | Human immunodeficiency virus 2 | RGLAA + PQFSL | - |
? | |
RPQNFLQSRP + H2O | oligopeptide representing cleavage sites in HIV-1 Gag and Gag-Pol polyproteins, location of cleavage NC/p6 | Human immunodeficiency virus 2 | ? | - |
? | |
TATIMMQRGN + H2O | oligopeptide representing cleavage sites in HIV-1 Gag and Gag-Pol polyproteins, location of cleavage X/NC | Human immunodeficiency virus 2 | TATIM + MQRGN | - |
? | |
VSQNYPIVQ + H2O | oligopeptide representing cleavage sites in HIV-1 Gag and Gag-Pol polyproteins, location of cleavage MA/CA | Human immunodeficiency virus 2 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PR | - |
Human immunodeficiency virus 2 |
retroviral proteinase | - |
Human immunodeficiency virus 2 |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000025 | - |
DKELYPLTSL | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.00005 | - |
RPQNFLQSRP | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.0001 | - |
CTLNFPISP | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.000183 | - |
KPRNFPVAQV | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.000217 | - |
IPFAA-AQQRK | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.00025 | - |
KARVL-AEAMS | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.000267 | - |
AETFYVDGAA | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.000333 | - |
IRKILFLDG | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.000333 | - |
KARLM AEALK | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.000333 | - |
MSLNLPVAKV | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.00055 | - |
EKGGNYPVQHV | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.000717 | - |
RGLAAPQFSL | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.000967 | - |
L-threonyl-L-alanyl-L-threonyl-L-isoleucyl-L-methionyl-L-methionyl-L-glutaminyl-L-arginylglycyl-L-asparagine | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.00172 | - |
VSQNYPIVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.00283 | - |
AETFYVDGAA | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.00917 | - |
EKGGNYPVQHV | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.0117 | - |
KPRNFPVAQV | pH 5.6, 37°C | Human immunodeficiency virus 2 |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000025 | - |
VSFNF-PSI[CH2-NH]-PQITL | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
0.0006 | - |
CTLNF-PSI[CH2-NH]-PISP | pH 5.6, 37°C | Human immunodeficiency virus 2 |