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Literature summary for 3.4.23.47 extracted from

  • Gustchina, A.; Weber, I.T.; Wlodawer, A.
    Molecular modeling of the HIV-2 protease (1991), Adv. Exp. Med. Biol., 306, 549-553.
    View publication on PubMed
Search for more literature for 3.4.23.47

Application

Application Comment Organism
medicine potential target for chemotherapy of virus infection and associated diseases, essential for maturation of infectious virions, development of drugs against the protease should be effective against HIV-2 Human immunodeficiency virus 2

Cloned(Commentary)

Cloned (Comment) Organism
cloned and sequenced Human immunodeficiency virus 2

Crystallization (Commentary)

Crystallization (Comment) Organism
crystallized by hanging drop method in complex with a reduced amide inhibitor, BI-LA-398 Human immunodeficiency virus 2

Inhibitors

Inhibitors Comment Organism Structure
acetyl-pepstatin common inhibitor of aspartic proteases Human immunodeficiency virus 2
H-261 renin inhibitor Human immunodeficiency virus 2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GAG precursor protein of HIV-2 + H2O Human immunodeficiency virus 2
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 2
-
 human immunodeficiency virus type 2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GAG precursor protein of HIV-2 + H2O
-
 Human immunodeficiency virus 2 ?
-
 ?

Subunits

Subunits Comment Organism
dimer symmetrical dimer of 2 subunits Human immunodeficiency virus 2