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Literature summary for 3.4.23.46 extracted from

  • Zhang, T.; Pan, B.S.; Zhao, B.; Zhang, L.M.; Huang, Y.L.; Sun, F.Y.
    Exacerbation of poststroke dementia by type 2 diabetes is associated with synergistic increases of beta-secretase activation and beta-amyloid generation in rat brains (2009), Neuroscience, 161, 1045-1056.
    View publication on PubMed
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
65000
-
 SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Rattus norvegicus
-
 fragments of amyloid precursor protein
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O
-
 Rattus norvegicus fragments of amyloid precursor protein
-
 ?

Synonyms

Synonyms Comment Organism
BACE1
-
 Rattus norvegicus
beta-secretase
-
 Rattus norvegicus
beta-site amyloid precursor protein-cleaving enzyme
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus exacerbation of poststroke dementia by type 2 diabetes is associated with synergistic increases of beta-secretase activation, high fat diet-streptozotocin treatment increases the stroke-induced elevation of BACE1 expression and activity in the rat hippocampus. Middle cerebral artery occlusion-high fat diet-streptozotocin rats demonstrate an increase in BACE1 mRNA to 239.6% 24 h after ischemic operation compared with sham-normal pellet diet rats up