Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.23.46 extracted from

  • McAllister, C.; Long, J.; Bowers, A.; Walker, A.; Cao, P.; Honda, S.; Harada, N.; Staufenbiel, M.; Shen, Y.; Li, R.
    Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment (2010), J. Neurosci., 30, 7326-7334.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.46

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Mus musculus BACE1 cleaves APP at the N-terminal end of the Abeta sequence, producing a 14000 Da C-terminal fragment beta or C99 fragments of amyloid precursor protein
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-amido-4-methylcoumarin-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-(Lys-2,4-dinitrophenyl)-OH + H2O
-
 Mus musculus ?
-
 ?
7-amido-4-methylcoumarin-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-(Lys-2,4-dinitrophenyl)-OH + H2O
-
 Mus musculus ?
-
 ?
amyloid precursor protein + H2O BACE1 cleaves APP at the N-terminal end of the Abeta sequence, producing a 14000 Da C-terminal fragment beta or C99 Mus musculus fragments of amyloid precursor protein
-
 ?

Synonyms

Synonyms Comment Organism
BACE-1
-
 Mus musculus
beta-secretase
-
 Mus musculus
beta-site APP cleaving enzyme 1
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus endogenous testosterone, independent of estrogen, downregulates BACE1 activities at transcriptional level. Heterozygous transgenic APP23/aromatase male mice exhibit decreased BACE1 protein expression and activity compared with control mice at age of 12 and 18 months down